Formulation and Evaluation of Proniosomal Gel in Ocular Drug

Raj K. Dhangar; Subhendu S. Mishra; Ashish Pathak; Navdeep Raghuwanshi; Sunil K. Yagnik; Amit Dubey; Devika Rawat

Raj K. Dhangar Department of Pharmaceutics, R.K.D.F College of Pharmacy, Bhopal, M.P., India,452016.
Subhendu S. Mishra Department of Pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India, 462021
Ashish Pathak Department of Pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India, 462021
Navdeep Raghuwanshi Department of Pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India, 462021
Sunil K. Yagnik Department of Pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India, 462021
Amit Dubey Department of Pharmaceutics, Sapience Bioanalytical Research Laboratory, Bhopal, M.P., India, 462021
Devika Rawat Chanakay mahavidhlaya kolar road Bhopal, M.P., India,

Abstract

The objective of the present investigation was to formulate and evaluate levofloxacin ocular film with proniosomes to increase the efficiency of drug providing sustained release action. The Proniosomes are relatively easy to make and less costly as compared to other novel formulation approaches. Proniosomes are promising drug carrier system which not only increase the stability profile of drug but also provide additional convenience in transportation, distribution, storage and dosing. The development of levofloxacin ocular films with proniosomes were novel approach toward the formulation of such product in marked. The aim of the study was to develop a proniosomal carriers system for levofloxacin for the treatment of bacterial conjunctivitis that is capable of efficiently delivering entrapped drug over an extended period of time and levofloxacin ocular films in proniosomal form enhance the contact time and spreadibility in the eye and provide sustained release action and better availability of drug. The use of levofloxacin in the proniosome preparation permitted flexibility in the amounts of surfactants and other components, which greatly enhances the potential application of proniosomes.

Keywords: Proniosomal, Levofloxacin, ocular films, Sustained Release, Gel