FORMULATION AND EVALUATION OF IN SITU GEL AS OPHTHALMIC DRUG DELIVERY SYSTEM
Abstract
Levofloxacin in situ gel is developed to overcome issues associated with traditional eye drops and to enhance their bioavailability. The low bioavailability of standard eye drops is primarily due to various precorneal loss factors. Additionally, this gel offers improved patient compliance through easier application and reduces the need for frequent instillations.
Keywords:
Levofloxacin, In situ gel, Ophthalmic drug delivery, In vitro Drug Release
References
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16. Naseem A, Charoo Kanchan K, Asgar A. Preparation of in situ forming ophthalmic gels of ciprofloxacin hydrochloride for the treatment of bacterial conjunctivitis: In vitro and In vivo studies. J Pharm Sci. 2003;92:407– 413.
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Impact of deep-freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions. Int J Pharm. 2002;234:205–207.
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27. Ashan, B, Jain DK, Tridevi P. Simultaneous spectrophotometric determination of Ciprofloxacin and Tinidazole in tablet. Indian Drugs. 1997;35:348-351.
28. Bourlais CAL, Acar LT, Rhodes CT, Sado PA, Leverge R. New Ophthalmic Drug Delivery Systems, Industrial Pharmacy. 1995;21:19-59.
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2. P Rose. Management strategies for acute infective conjunctivitis in primary care: a systematic review. Expert Opin Pharmacotherapy. 2007;8(12);21.
3. Peppas NA, Langer R. New challenges in biomaterials. Science. 1994;263:1715– 20.
4. Zhidong L, Jaiwei L, Shufang N, Hui L, Pingtian D, Weisan P. Study of an alginate/HPMC based in situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm. 2006;315:12–7.
5. Sasaki H, Yamamura K, Nishida K, Nakamurat J, Ichikawa M, ―Delivery of drugs to the eye by topical application. Progress in Retinal and Eye Research. 1996;15(2):553-620.
6. Mitra, A.K. (Ed.). Ophthalmic Drug Delivery Systems (2nd ed.). CRC Press. 2003;1-3 https://doi.org/10.1201/9780203912072
7. Mundada AS, Avari JG, Mehta SP, Pandit SS, Patil AT. Recent advances in ophthalmic drug delivery system. Pharm Rev. 2008;6(1):7-13.
8. Wagh VD, Inamdar B, Samanta MK. Polymers used in ocular dosage form & drug delivery system. Asian J Pharm. 2008;2(1):12-17.
9. Indu PK, Manjit S, Meenakshi K. Formulation and evaluation of ophthalmic preparations of acetazolamide. Int J Pharm. 2000;199: 119–127.
10. Zhidong L, Jiawei L, Shufang N, Hui L, Pingtian D, Weisan P. Study of an alginate/HPMC based in situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm. 2006;315:12–17. [223Hdoi:10.1016/j.ijpharm.2006.01.029]
11. Indu PK, Manjit S, Meenakshi K. Formulation and evaluation of ophthalmic preparations of acetazolamide.Int J Pharm. 2000;199: 119–127.
12. Bourlais CL, Acar L, Zia H, Sado PA, Needham T, Levergc R, ―Ophthalmic drug delivery systems recent advances. Progress in Retinal and Eye Research 1998;7(1):33-58.
13. Pandit D, Bharathi A, Srinatha R, Singh S. Long acting ophthalmic formulation of indomethacin: Evaluation of alginate gel systems. Indian J Pharm Sci. 2007;69:37–40.
14. Johan C, Katarina E, Roger P, Katarina, J. Rheological evaluation of gelrite in situ gel for opthalmic use. Eur J Pharm Sci. 1998;6:113–116.
15. Katarina E, Johan C, Roger, P. Rheological evaluation of poloxamer as an in situ gel for ophthalmic use. Eur J Pharm Sci. 1998;6:105–112.
16. Naseem A, Charoo Kanchan K, Asgar A. Preparation of in situ forming ophthalmic gels of ciprofloxacin hydrochloride for the treatment of bacterial conjunctivitis: In vitro and In vivo studies. J Pharm Sci. 2003;92:407– 413.
17. Sautou-Miranda V, Labret F, Grand-Boyer A, Gellis C, Chopineau J.
Impact of deep-freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions. Int J Pharm. 2002;234:205–207.
18. Indian Pharmacopoiea, Vol. – I, Government of India. Ministry of health and family welfare. The controller of Publications, Delhi. 1996:100–124.
19. Doijad RC, Manvi FV, Malleswara Rao VSN, Prajakta Alsae. Sustained ophthalmic delivery of gatifloxacin from in situ gelling system. Indian J Pharm Sci. 2006;68:814–818.
20. Zabransky RJ. Linezolid: The first class of a new class of antimicrobial agents. Clin Microbiol Newsl. 2002;24:25–30.
21. Martha J, Gentry N, Keith M, Olsen, Laurel CP. Pharmacodynamic activity and efficacy of linezolid in a rat model of Pneumococcal pneumonia. Antimicrob Agents Chemother. 2002;46:1345–1396.
22. SR Waltman, Patrowicz TC. Invest Ophthalmol. Visual Sci. 1970;9:966-973.
23. Chrai SS, J Robinson. J. Pharma. Sci., 1974;63:1218-1222.
24. Rojanasakul Y, Wang LY, Bhat M, Glover DD, Malanga CJ, J Ma. The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit. Pharm. Res. 1992; 9:1029–1034.
25. Patton TF, Robinson JR. J. Pharm. Sci. 1975;64:1312-131.
26. Ainley W. In Martindale: The extra Pharmacopoeia, 27th edition, The Pharmaceutical Press, London, 185-189.
27. Ashan, B, Jain DK, Tridevi P. Simultaneous spectrophotometric determination of Ciprofloxacin and Tinidazole in tablet. Indian Drugs. 1997;35:348-351.
28. Bourlais CAL, Acar LT, Rhodes CT, Sado PA, Leverge R. New Ophthalmic Drug Delivery Systems, Industrial Pharmacy. 1995;21:19-59.
29. Bourlais CAL, Acar LT, Zia H, Sado PA, Leverge R. Ophthalmic drug delivery systems recent advance. Industrial Pharmacy. 1998;17:33-58.
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How to Cite
Madhu Kumari, Nilesh Gupta, and Umesh Kumar Jain. “FORMULATION AND EVALUATION OF IN SITU GEL AS OPHTHALMIC DRUG DELIVERY SYSTEM”. Current Research in Pharmaceutical Sciences, Vol. 15, no. 2, Aug. 2025, pp. 58-62, doi:10.24092/CRPS.2025.150205.
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Research Articles
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