THERAPEUTIC EVALUATION OF CANNABIDIOL NANO-CREAM IN UVB-INDUCED PSORIASIS RAT MODEL
Abstract
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes, immune cell infiltration, and erythematous plaques. This study aimed to evaluate the therapeutic efficacy of a cannabidiol (CBD) nano-cream in a UVB-induced psoriasis rat model. The nano-cream was formulated using a nanoemulsion-based system to enhance dermal delivery and sustained release of CBD. Characterization studies confirmed optimal pH, viscosity, spreadability, and high drug content. The anti-psoriatic potential was assessed by evaluating histopathological changes, Psoriasis Area Severity Index (PASI), and epidermal thickness in Wistar rats exposed to UVB radiation. Results demonstrated that the CBD nano-cream significantly reduced inflammation, erythema, and epidermal hyperplasia compared to control groups. The findings support the potential of CBD nano-cream as a promising topical therapeutic approach for the treatment of psoriasis.
Keywords:
Cannabidiol, Psoriasis, Nano-cream, UVB-induced model, Topical delivery, Wistar rats
References
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15. Rizvi D A, Fatima Z, & Kaur CD. Antipsoriatic and anti-inflammatory studies of Berberis aristata extract loaded nanovesicular gels. Pharmacognosy magazine. 2017;13(Suppl 3):S587.
2. Elgewelly MA, Elmasry SM, Sayed NS, & Abbas H. Resveratrol-loaded vesicular elastic nanocarriers gel in imiquimod-induced psoriasis treatment: in vitro and in vivo evaluation. Journal of Pharmaceutical Sciences. 2022;111(2):417-431.
3. Parveen S, Ahmed M, Baboota S, & Ali J. An innovative approach in nanotechnology-based delivery system for the effective management of psoriasis. Current Pharmaceutical Design. 2022;28(13):1082-1102.
4. Shahine Y, El-Aal SA, Reda AM, Sheta E, Atia NM, Abdallah OY, & Ibrahim SS. Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance. Inflammopharmacology. 2023;31(3):1341–1359.
5. Khatoon K, Ali A, Ahmad FJ, Hafeez Z, Rizvi MMA, Akhter S, & Beg S. Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: In vitro and in vivo studies. Drug delivery and translational research. 2021;11:1245-1260.
6. Rapalli VK, Sharma S, Roy A, Alexander A, & Singhvi G. Solid lipid nanocarriers embedded hydrogel for topical delivery of apremilast: In vitro, ex-vivo, dermatopharmacokinetic and anti-psoriatic evaluation. Journal of Drug Delivery Science and Technology. 2021;63:102442.
7. Pandey SS, Shah KM, Maulvi FA, Desai DT, Gupta AR, Joshi SV, & Shah DO. Topical delivery of cyclosporine loaded tailored niosomal nanocarriers for improved skin penetration and deposition in psoriasis: Optimization, ex vivo and animal studies. Journal of Drug Delivery Science and Technology. 2021;63:102441.
8. Tambe VS, Nautiyal A, & Wairkar S. Topical lipid nanocarriers for management of psoriasis-an overview. Journal of Drug Delivery Science and Technology. 2020;64:102671.
9. Fukuta T, Oshima Y, Michiue K, Tanaka D, & Kogure K. Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment. Journal of controlled release. 2020;323:323-332.
10. Filippone A, Consoli GM, Granata G, Casili G, Lanza M, Ardizzone A, ... & Paterniti I. Topical delivery of curcumin by choline-calix, arene-based nanohydrogel improves its therapeutic effect on a psoriasis mouse model. International Journal of Molecular Sciences. 2020;21(14):5053.
11. Bahramizadeh M, Bahramizadeh M, Kiafar B, Jafarian AH, Nikpoor A R, Hatamipour M, ... & Jafari M R. Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model. International journal of pharmaceutics. 2019;569:118623.
12. Siddiqui DES, Afroz S, & Khan RA. Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats. Pakistan Journal of Pharmaceutical Sciences. 2019;32(1).
13. Raghuwanshi N, Yadav TC, Srivastava AK, Raj U, Varadwaj P, & Pruthi V. Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model. Materials Science and Engineering. 2019;95:57-71.
14. Okasha EF, Bayomy NA, & Abdelaziz EZ. Effect of topical application of black seed oil on imiquimod‐induced psoriasis‐like lesions in the thin skin of adult male albino rats. The Anatomical Record. 2018;301(1): 166-174.
15. Rizvi D A, Fatima Z, & Kaur CD. Antipsoriatic and anti-inflammatory studies of Berberis aristata extract loaded nanovesicular gels. Pharmacognosy magazine. 2017;13(Suppl 3):S587.
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How to Cite
Aakashsinh Vaghela, and Neeraj Sharma. “THERAPEUTIC EVALUATION OF CANNABIDIOL NANO-CREAM IN UVB-INDUCED PSORIASIS RAT MODEL”. Current Research in Pharmaceutical Sciences, Vol. 15, no. 2, Aug. 2025, pp. 40-44, doi:10.24092/CRPS.2025.150202.
Section
Research Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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