SYNTHESIS AND EVALUATION OF PRODRUG OF NSAIDS FOR REDUCTION OF ULCEROGENECITY

Niraj Kumar; Rakesh Kumar Gawaly

doi:10.24092/CRPS.2025.150103

Niraj Kumar Oriental College of Pharmacy, Bhopal, M.P., India
Rakesh Kumar Gawaly Oriental College of Pharmacy, Bhopal, M.P., India

DOI https://doi.org/10.24092/CRPS.2025.150103

Abstract

The ester prodrugs are for enhancing the anti-inflammatory activity and for reduction of ulcerogenic effects of NSAIDs. Also, the studies attempted to evaluate the pharmacokinetics of the prodrugs by in-vitro methods. The inflammation induced by carrageenan that is an acute model. The carriers used in research work, sesamol, umbelliferone and thymol, also produced anti-inflammatory activity and antioxidant effects. Therefore, overall, the synthesized products showed synergistic anti-inflammatory activity. The natural phenolic antioxidants for synthesizing the ester prodrugs are sesamol, 4- methyl umbelliferone and thymol and that itself showed various pharmacological activities.

Keywords: NSAIDs, prodrug, antioxidants, umbelliferone, analgesic activity, anti-inflammatory activity

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