FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF WATER SOLUBLE DRUG BY HOT MELT TECHNIQUE

  • Arif Khan Bhopal institute of Technology & Science -Pharmacy, Bhopal, M. P. India
  • Ajay Patel Bhopal institute of Technology & Science -Pharmacy, Bhopal, M. P. India
  • Nilesh Gupta Bhopal institute of Technology & Science -Pharmacy, Bhopal, M. P. India
  • U. K. Jain Bhopal institute of Technology & Science -Pharmacy, Bhopal, M. P. India

Abstract

Sustained release tablets were prepared by melt granulation method. In present investigation attempt was made to prepare sustain release Matrix Tablet formulation of Timolol hydrochloride using cetostearyl alcohol and hydroxy propyl cellulose. Physical characteristic of prepared blend and evaluation parameters are in limits  Batch F5  shows better release profile. So, from that it can conclude that cetostearyl alcohol retard the release of drug in better manner for 24 hrs.

Keywords: sustain release, timolol, dissolution, melt granulation, wax

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How to Cite
Arif Khan, Ajay Patel, Nilesh Gupta, and U. K. Jain. “FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF WATER SOLUBLE DRUG BY HOT MELT TECHNIQUE”. Current Research in Pharmaceutical Sciences, Vol. 14, no. 3, Oct. 2024, pp. 41-47, doi:10.24092/CRPS.2024.140303.
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Research Articles