A life threatening lung disease of Bundelkhand region- Silicosis
Abstract
Silica is the second most common element on the surface of the earth. It is found in sand, many rocks such as granite, sandstone, flint and slate, and in some coal and metallic ores. The cutting, breaking, crushing, drilling, grinding, or abrasive blasting of these materials may produce fine silica dust. Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust, and is marked by inflammation and scarring in forms of nodular lesions in the upper lobes of the lungs. Silicosis is due to deposition of fine dust (less than 1μm in diameter) containing crystalline silicon dioxide in the form of alpha-quartz, cristobalite, or tridymite. Silicosis is characterized by shortness of breath, fever, and cyanosis. It may often be misdiagnosed as pulmonary edema (fluid in the lungs), pneumonia, or tuberculosis. Treatment options currently focus on alleviating the symptoms and preventing complication. So here an attempt has been made to attract the attention of doctors, researchers, NGO’s to develop a proper medication and vaccine kit for the complete treatment of this disease.
References
2. Banks DE, Balaan M, Wang ML. Silicosis in the 1990s, revisited. Chest. Apr 1997; 111(4):837-8.
3. Rosenman KD, Moore-Fuller M, Reilly MJ. Connective tissue disease and silicosis. Am J Ind Med. Apr 1999; 35(4):375-81.
4. Caplan A, Payne RB, Withley JL. A broadened concept of Caplan's syndrome related to rheumatoid factors. Thorax. 1962; 17:205-209.
5. Graham WGB. Quartz and silicosis. In: Banks D, Parker J, eds. Occupational Lung Disease: An International Perspective. New York, NY: Chapman & Hall Medical (1998) 191-212.
6. Hertzberg VS, Rosenman KD, Reilly MJ, Rice CH. Effect of occupational silica exposure on pulmonary function. Chest. 2002; 122(2) : 721-8.
7. Wagner GR. Screening and surveillance of workers exposed to mineral dusts. Geneva, World Health Organization. 1996.
8. Gamble JF, Hessel PA, Nicolich M. Relationship between silicosis and lung function. Scand J Work Environ Health. Feb 2004; 30(1):5-20.
9. Steenland K, Goldsmith DF (November 1995). Silica exposure and autoimmune diseases. National Institute for Occupational Safety and Health (2007) 05-29
10. Ghio AJ, Kennedy TP, Schapira RM, Crumbliss AL. Hoidal JR. Hypothesis: silicosis is lung disease after silicate inhalation caused by oxidant generation? Lancet. Oct 20 1990; 336(8721):967-9.
11. Attfield MD, Costello J. Quantitative exposure-response for silica dust and lung cancer in Vermont granite workers. Am J Ind Med. Feb 2004; 45(2):129-38.
12. Centers for Disease Control and Prevention. Silicosis in dental laboratory technicians--five states, 1994-2000. MMWR Morb Mortal Wkly Rep. Mar 12 2004; 53(9):195-7.
13. Arakawa H, Honma K, Saito Y, Shida H, Morikubo H, Suganuma N. Pleural disease in silicosis: pleural thickening, effusion, and invagination. Radiology. Aug 2005; 236(2):685-93.
14. Cassel SL, Eisenbarth SC, Iyer SS. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. 2008; 105: 9035.
15. Corbett EL, Churchyard GJ, Clayton T, Herselman P, Williams B, Hayes R. Risk factors for pulmonary mycobacterial disease in South African gold miners. A case-control study. Am J Respir Crit Care Med. 1999; 159(1):94-9.
16. American Thoracic Society Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med. 2000; 161(4 Pt 2):S221-47.
17. Corbett EL, Murray J, Churchyard GJ, Herselman PC, Clayton TC, De Cock KM. Use of miniradiographs to detect silicosis. Comparison of radiological with autopsy findings. Am J Respir Crit Care Med. Dec 1999; 160(6):2012-7.
18. "Safety and Health Topics Silica, Crystalline" Occupational Safety and Health Administration. March 2007.
19. "Silicosis Fact Sheet". World Health Organization. (May 2000) 05-29.
20. Lapp NL. Pulmonary function and disability. In: Banks D, Parker J, eds. Occupational Lung Disease: An International Perspective. 1998. New York, NY: Chapman & Hall Medical (1998) 17-34.
21. Goodman GB, Kaplan PD, Stachura I, Castranova V, Pailes WH, Lapp NL. Acute silicosis responding to corticosteroid therapy. Chest. Feb 1992; 101(2):366-70.
22. Sharma SK, Pande JN, Verma K. Effect of prednisolone treatment in chronic silicosis. Am Rev Respir Dis. Apr 1991; 143(4 Pt 1):814-21.
23. McDonald JC, McDonald AD, Hughes JM, Rando RJ, Weill H. Mortality from lung and kidney disease in a cohort of North American industrial sand workers: an update. Ann Occup Hyg. Jul 2005; 49(5):367-73.
24. National Archives and Records Administration. United States code of federal regulations. 1910.1000. Office of the Federal Register, National Archives and Records Administration; 1994.
25. Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med. Mar 2005; 11(2):169-73.
26. Valiante DJ, Schill DP, Rosenman KD, Socie E. Highway repair: a new silicosis threat. Am J Public Health. May 2004; 94(5):876-80.
.