Formulation and In vitro Evaluation of Divalproex Sodium Bi-Layered Tablet
Abstract
Divalproex sodium is the anticonvulsant agents that used in the treatment certain types of seizures. The aim of the present study is to formulate and evaluate divalproex sodium bilayer tablet. Divalproex Sodium Bi-layer tablets (BLT) were prepared by simple blending and punching with HPMC, Xanthan Gum, Sodium starch glycolate, MCC, PVP, and Magnesium stearate. Optimized formulation was designed on the basis of best formulation of the immediate release layer and sustained release layer. The pre and post compression parameters were evaluated and stability studies of the optimized formulation was also performed. FTIR studies was checked and no interaction found between the drug and polymers. Optimized tablet batch had shown excellent range in weight variation (553.2±1.42) mg, thickness (4.9±0.52) mm, Diameter (1.4±0.13) cm, hardness (5.2±0.31) Kg/cm2, friability (0.35±0.10) % and % drug content (99.34±1.6) %. IRL-5 and SRL-3 showed excellent drug release of 98.13 and 95.74% from all formulation’s layers. Divalproex Sodium Bi-layer tablet (BLT) was formulated by combining both layers IRL- 5 and SRL-3. The stability study was shown that optimized formulation stable at 45 ±2 0C for 45 days. So that, the optimized formulation might be suitable for the treatment of seizures.
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