Formulation and Evaluation of Polyherbal Emulgel for Treatment of Acne
Abstract
Skin disease is a persistent inflammatory skin disorder that affects around 70% of teenage females throughout puberty. To counteract this problem, antibiotics are being administered more often, which has resulted in a variety of undesirable side effects. As a result, as a first-line topical therapy, it must target on the herbal formulation. In this study, medicinal plant extracts and oils with high antibacterial activity, such as Curcuma longa and Aloe barbadensis, tea tree oil, and lemongrass oil, were chosen to produce a polyherbal emulgel for the treatment of acne vulgaris. Curcuma longa, Aloe barbadensis, tea tree oil, and lemongrass oil were all extracted and reported in this study. Lemongrass oil, tea tree oil, aloe Vera extract, and turmeric extract were used in various amounts in the topical gels. After being kept at room temperature for 24 hours, the gel was prepared and evaluated. As a result of the study's findings, a prepared polyherbal emulgel containing extracts of Curcuma longa, lemon grass oil and tea tree oil at concentrations of 0.5 percent, 5 percent, 5 percent respectively, can be used to treat acne vulgaris.
References
2. Bonifant H, Holloway S. A review of the effects of ageing on skin integrity and wound healing. British J Community Nurs. 2019;24:S28-S33.
3. Ter Horst B, Chouhan G, Moiemen NS, Grover LM. Advances in keratinocyte delivery in burn wound care. Advanced drug delivery reviews. 2018;123: 18-32.
4. Meenakshi D. Emulgel: A Novel Approach to Topical Drug Delivery. Int J Pharm Bio Science 2013; 4: 847-856.
5. Mohamed MI. Optimization of Chlorphenesin Emulgel Formulation. The AAPS J.2004; 6: 1-7.
6. Khalil RM, Abd El Rahman AA, Kassem MA, El Ridi MS, Abou samra MM, Awad GE, Mansy SS. Preparation and in vivo Assessment of Nystatin-Loaded solid Lipid Nanoparticles for Topical Delivery against Cutaneous. Biomedical and Pharmaceutical Engineering. 2014;8: 34-36.
7. Prajapati BG and Patel MM. Crosslinked chitosan gel for local drug delivery of clotrimazole. J Sci Tec .2010;6: 43-52.
8. Bachhav YG and Patravale VB. Microemulsion-Based Vaginal Gel of Clotrimazole: Formulation, In Vitro Evaluation, and Stability Studies. AAPS Pharm Sci Tech.2009; 10:476-482.
9. Bandyopadhyay P, Neeta NS. Evidence for vesicle formation from 1:1 non-ionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: Potential delivery vehicle composition Colloids and Surfaces. 2007; 58:305-308.
10. Shah AA, Kamdar K, Shah R, Keraliya R.A. Emulgel- A Topical Preparation for Hydrophobic Drugs. Ph Tech. Med. 2013;2(5):370-376.

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