Formulation and Evaluation of Emulgel of Cephalexin to Enhance Topical Delivery

Lokesh Shakya; Pradeep Chauhan; Bharat Kumar Tyagi

doi:10.24092/CRPS.2020.100401

Lokesh Shakya Institute of Professional Studies, College of Pharmacy, Gwalior (M P)
Pradeep Chauhan Institute of Professional Studies, College of Pharmacy, Gwalior (M.P.)
Bharat Kumar Tyagi Institute of Professional Studies, College of Pharmacy, Gwalior (M.P.)

DOI https://doi.org/10.24092/CRPS.2020.100401

Abstract

Emulgel dosage formulation of cephalexin which has enhanced solubility release and bioavailability properties with less inter and intra - subject variability would be desirable. Thus, it was aimed to formulate and evaluate emulgels ofthe cephalexin. By the preformulation studies it is observed that cephalexin is a white to off white amorphous powder having no odor and characterstic taste. Five different type formulations (E-1 to E-5) formed using oil phase having fixed amount of Capric/caprylic Triglyceride (CT) and different ration of Cetyl Palmitate (CP) and fixed quantity of oil soluble emulsifiers Cetyl dimethicone copolyol (CDC) and Sorbitan stearate (Span 60) with Aqueous Phase contain Purified water at pH 6.8. Then observed visually that all formulations were clear, there was no phase separation and Stable during Thermo dynamic changes, heating cooling cycle and centrifugation stressed test. Characterization of all cephalexin emulsion formulations were evaluated for Droplet size, Zeta potential and Poly Dispersity Index (PDI) and % drug content, all emulgels showed excellent results droplet size was found between 1.12 to1.97 µm. All five cephalexin emulgel formulations were odorless, washable, homogeneous, stable and free from grittiness and was evaluated under the various parameters, pH of all formulations were observed at 6.8 and viscosity between 40.23 to 76.38 centi Poise and spreaability between 4.326 to 5.341 gm.cm/sec. In-vitro Drug Release of Cephalexin emulgel formulations were studied and found EG-1 (64.75), EG-2 (68.37), EG-3 (51.32), EG-4 (90.32) and EG-5(94.89). Emulgel formulations EG-4 and EG-5 were found excellent on the basis of cumulative percentage of drug release profile. Release data of both selected formulations was fitted into kinetic models. Drug release data were fitted into the zero order, first order, Higuchi and Peppas-Korsemeyer model of drug release kinetics. Emulgel EG-4 and EG-5 both were followed Zero Order Kinetics explained as continuous and steady release of Cephalexin from the formulation. All five formulations were also tested for stability and found formulation EG-3, EG-4 and EG-5 were stable after 30 days against color change, creaming, creaking and phase separation.

Keywords: Emulgel, Cephalexin, Topical delivery, Cetyl dimethicone copolyol, Cetyl Palmitate

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