The Role, Scope, Health Benefits and Market Growth of Nutraceuticals: An Overview
Abstract
Nutraceuticals are products used as medicines in addition to nutrition. Nutraceuticals can be defined as substances that have physiological benefits or provide protection against chronic disease. Nutraceuticals can be used to improve health, slow down the aging process, prevent chronic diseases, increase life expectancy or support body structure or function. Nutraceuticals are getting a lot of attention these days because of their potential nutritional, safety and therapeutic benefits. Recent studies have shown that these compounds have promising results in various complications. In this review, we have made a great effort in proposing new concepts for nutraceuticals based on disease indications. Highlights herbal remedies that are effective for harsh therapeutic conditions associated with oxidative stress, including allergies, Alzheimer's disease, cardiovascular disease, cancer, diabetes, eye, immunity, inflammation, and Parkinson's disease and obesity. These nutraceuticals are used in various diseases, their application, and current market demand. Examples of fish oil preparations, prebiotics and probiotics reviewed.
Keywords:
Nutraceutical, Dietary supplements, Antioxidants, Probiotics, Health benefits
References
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5. RajasekaranA, SivagnanamG and Xavier R. Nutraceuticals as therapeutic agents: A Review. Research Journal of Pharmacy and Technology.2008; 1(4): 328-340.
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11. Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem. 2002; 50: 6182-6187.
12. Alasalvar C, Shahidi F, Quantick P. Food and health applications of marine nutraceuticals:AReview.SeafoodsQuality,technology and nutraceutical applications. New York (2002) 175-204.
13. Halliwell B, Antioxidants in human health and disease. Ann Rev Nutr. 1996; 16: 33-50
14. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006; 15:118-23.
15. Jha SK, Roy P, Chakrabarty S. Nutraceuticals with pharmaceuticals its importance and their application. International journal of drug development and research. 2020;1.
16. NwosuOK, UbaojiKI. Nutraceuticals: History, Classification and Market Demand. Functional Foods and Nutraceuticals. 2020; 13–22.
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20. Michail S, Sylvester F, Fuchs G, Issenma R. Clinical efficacy of probiotics: Review of the evidence with focus on children. Clinical practice guideline. J Paediatric Gastroenterol Nutrition. 2006; 43(4): 550-557.
21. Holzapfel WH, Haberer P, Geisen R, Bjorkroth J, Schillinger U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr. 2001; 73(2):365–373.
22. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr. 2019; 59(11):1675–1683.
23. Verma G. International Journal of Pharmacy & Therapeutics, 2016; 7(4): 152-160.
24. Sazawal S, Dhingra U, Hiremath G, Sarkar A, Dhingra P, Dutta A, Verma P, Menon VP, Black RE. Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial. PLoS One. 2010; 5(8):12164.
25. Hyvonen P, Suojala L, Orro T, Haaranen J, Simola O, Rontved C, Pyorala SP.Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli Intramammary Infection. Infect Immun. 2006; 74:6206–6212.
26. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006; 15: 23-118.
27. Devi VK, Rehman F. Nutraceutical antioxidants-An overview, Indian journal of pharmaceutical education. 2002; 36(1):3-8.
28. Bell SJ, Goodrick GK. A Functional Food Product for the Management of Weight Critical Reviews in Food Science and Nutrition. 2002; 42: 163-178.
29. Brouns F. Soya isoflavones: a new and promising ingredient for the health foods sector. Food Research International. 2002; 35: 187-193.
30. Sirtori CR, Galli C.Fatty acids and the Omega 3.Biomedicine and Pharmacotherapy. 2002; 56: 397-406.
31. Bland JS. Phytonutrition, phytotherapy, and phytopharmacology. Altern Ther HealthMed. 1996; 2:73-76.
32. Ernst E. Functional foods, nutraceuticals, designer foods: innocent fad or counterproductive marketing ploy. Eur J Clin Pharmacol. 2001; 57:353–355.
33. Dr. Zeeshan Afsar. Essential of herbal drug technology. 2020 edition. PV publication, Panjab, India (2020) Page No. 33.
34. Verma G. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
35. Verma G. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
36. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytother Res. 2007; 21(1): 17-25.
37. Larussa T,Imeneo M,Luzza F. World J Gastroenterol, 2017; 23(14): 2483-2492.
38. Caterson ID, Gill TP. Obesity: epidemiology and possible prevention. Best Pract Res Clin Endocrinol Metab. 2002; 16(4): 595-610.
39. Cencic A. The Role of Functional Foods, Nutraceuticals, and Food Supplements in Intestinal Health, Nutrients. 2010; 2: 611-625.
40. Mishra MK. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
41. Pandey M. Nutraceuticals: new era of medicine and health. Asian journal of clinical nutrition. 2010; 3(1):
42. Witkamp RF, Van Norren K. Let thy food be thy medicine when possible. Eur J Pharmacol. 2018; 836: 102-114.
43. Subbiah MR. Understanding the nutrigenomic definition and concepts at the food-genome junction. Omics A journal of integrative Biology. 2008; 12: 229-235.
44. Zelig R,Rigassio RD. Understanding the properties of common dietary supplements: Clinical implication for healthcare practitioners. Nutr Clin Pract. 2012; 27: 767-776.
45. Costello RB, Coates P. In the midst of confusion lies opportunity: Fostering quality science in dietary supplement research. J Am Coll Nutr. 2001; 20: 21-25.
46. Pawar RS, Tamta H, Ma J, Krynitsky AJ, Grundel E. Updates on chemical and biological research on botanical ingredients in dietary supplements. Anal Bioanal Chem. 2003; 405: 4373-4384.
47. Huang Q, Yu H, Ru Q. Bioavailability and delivery of nutraceuticals using nanotechnology. J of food sci. 2010; 75: 50-57.
48. Shoji Y, Nakashima H. Nutraceuticals and delivery systems. J Drug Target. 2004; 12: 385-391.
49. Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev med. 2014; 5: 1487-99.
50. Gulati OP, Berry OP. Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicology. 2006; 221: 75-87.
51. Nutraceuticals Market by Product and Geography - Forecast and Analysis2020-2025 by https://www.technavio.com/report/nutraceuticals-market-industry-analysis.
52. Brower B. Nutraceuticals: Poised for a healthy slice of the market. Nature Biotechnology. 1998; 16:728-33.
53. Mannion M. Nutraceutical revolution continues at Foundation for Innovation in Medicine Conference. American Journal of Natural Medicine. 1998;5:30-3.
2. Brower V. Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol. 1998; 16:728-731.
3. Zeisel SH. Regulation of “Nutraceuticals”. Science. 1999;285:185-186.
4. Cencic A, Chingwaru W. Role of functional foods, nutraceuticals and food supplements in intestinal health. Nutrients. 2010; 2(6):611–625.
5. RajasekaranA, SivagnanamG and Xavier R. Nutraceuticals as therapeutic agents: A Review. Research Journal of Pharmacy and Technology.2008; 1(4): 328-340.
6. Pandey M, Verma KR, Saraf A.Nutraceuticals: New Era of Medicine and Health. Asian Journal of Pharmaceutical and Clinical Research. 2010; 3(1): 1-2.
7. Allen LV. Nutritional products, In: Covington TR, Berardi RR, Young LL, Kendall SC, Hickey MJ, editors. Handbook of Nonprescription Drugs. Washington DC: American Pharmaceutical Association (1997).
8. Kasbia GS. Functional Foods and Nutraceuticals in the Management of obesity. Nutrition and Food Science. 2005; 35: 344-351.
9. Elizabeth AC. Over-the-counter products: nonprescription medications, nutraceuticals, and herbal agents. Clin Obstet Gynecol. 2002; 45(1):89-98.
10. Whitman M.Understanding the perceived need for complementary and alternative nutraceuticals: lifestyle issues. Clin J Oncol Nurs. 2001; 5:190-194.
11. Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem. 2002; 50: 6182-6187.
12. Alasalvar C, Shahidi F, Quantick P. Food and health applications of marine nutraceuticals:AReview.SeafoodsQuality,technology and nutraceutical applications. New York (2002) 175-204.
13. Halliwell B, Antioxidants in human health and disease. Ann Rev Nutr. 1996; 16: 33-50
14. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006; 15:118-23.
15. Jha SK, Roy P, Chakrabarty S. Nutraceuticals with pharmaceuticals its importance and their application. International journal of drug development and research. 2020;1.
16. NwosuOK, UbaojiKI. Nutraceuticals: History, Classification and Market Demand. Functional Foods and Nutraceuticals. 2020; 13–22.
17. Chauhan B, Kumar G, Kalam N, Ansari SH. Current concepts and prospects of herbal nutraceutical: AReview. J Adv Pharm Technol Res. 2013; 4(1):4–8.
18. Ehrlich SD. Peppermint (Mentha piperita): private practice specializing in complementary and alternative medicine. Phoenix, AZ. Review. VeriMed Healthcare Network. 2009.
19. Zhao J. Nutraceuticals, nutritional therapy, phytonutrients, and phytotherapy for improvement of human health: a perspective on plant biotechnology application. Bentham Science Publishers. 2007; 1: 75-97.
20. Michail S, Sylvester F, Fuchs G, Issenma R. Clinical efficacy of probiotics: Review of the evidence with focus on children. Clinical practice guideline. J Paediatric Gastroenterol Nutrition. 2006; 43(4): 550-557.
21. Holzapfel WH, Haberer P, Geisen R, Bjorkroth J, Schillinger U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am J Clin Nutr. 2001; 73(2):365–373.
22. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr. 2019; 59(11):1675–1683.
23. Verma G. International Journal of Pharmacy & Therapeutics, 2016; 7(4): 152-160.
24. Sazawal S, Dhingra U, Hiremath G, Sarkar A, Dhingra P, Dutta A, Verma P, Menon VP, Black RE. Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial. PLoS One. 2010; 5(8):12164.
25. Hyvonen P, Suojala L, Orro T, Haaranen J, Simola O, Rontved C, Pyorala SP.Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli Intramammary Infection. Infect Immun. 2006; 74:6206–6212.
26. Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev. 2006; 15: 23-118.
27. Devi VK, Rehman F. Nutraceutical antioxidants-An overview, Indian journal of pharmaceutical education. 2002; 36(1):3-8.
28. Bell SJ, Goodrick GK. A Functional Food Product for the Management of Weight Critical Reviews in Food Science and Nutrition. 2002; 42: 163-178.
29. Brouns F. Soya isoflavones: a new and promising ingredient for the health foods sector. Food Research International. 2002; 35: 187-193.
30. Sirtori CR, Galli C.Fatty acids and the Omega 3.Biomedicine and Pharmacotherapy. 2002; 56: 397-406.
31. Bland JS. Phytonutrition, phytotherapy, and phytopharmacology. Altern Ther HealthMed. 1996; 2:73-76.
32. Ernst E. Functional foods, nutraceuticals, designer foods: innocent fad or counterproductive marketing ploy. Eur J Clin Pharmacol. 2001; 57:353–355.
33. Dr. Zeeshan Afsar. Essential of herbal drug technology. 2020 edition. PV publication, Panjab, India (2020) Page No. 33.
34. Verma G. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
35. Verma G. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
36. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytother Res. 2007; 21(1): 17-25.
37. Larussa T,Imeneo M,Luzza F. World J Gastroenterol, 2017; 23(14): 2483-2492.
38. Caterson ID, Gill TP. Obesity: epidemiology and possible prevention. Best Pract Res Clin Endocrinol Metab. 2002; 16(4): 595-610.
39. Cencic A. The Role of Functional Foods, Nutraceuticals, and Food Supplements in Intestinal Health, Nutrients. 2010; 2: 611-625.
40. Mishra MK. International Journal of Pharmacy & Therapeutics. 2016; 7(4): 152-160.
41. Pandey M. Nutraceuticals: new era of medicine and health. Asian journal of clinical nutrition. 2010; 3(1):
42. Witkamp RF, Van Norren K. Let thy food be thy medicine when possible. Eur J Pharmacol. 2018; 836: 102-114.
43. Subbiah MR. Understanding the nutrigenomic definition and concepts at the food-genome junction. Omics A journal of integrative Biology. 2008; 12: 229-235.
44. Zelig R,Rigassio RD. Understanding the properties of common dietary supplements: Clinical implication for healthcare practitioners. Nutr Clin Pract. 2012; 27: 767-776.
45. Costello RB, Coates P. In the midst of confusion lies opportunity: Fostering quality science in dietary supplement research. J Am Coll Nutr. 2001; 20: 21-25.
46. Pawar RS, Tamta H, Ma J, Krynitsky AJ, Grundel E. Updates on chemical and biological research on botanical ingredients in dietary supplements. Anal Bioanal Chem. 2003; 405: 4373-4384.
47. Huang Q, Yu H, Ru Q. Bioavailability and delivery of nutraceuticals using nanotechnology. J of food sci. 2010; 75: 50-57.
48. Shoji Y, Nakashima H. Nutraceuticals and delivery systems. J Drug Target. 2004; 12: 385-391.
49. Nasri H, Baradaran A, Shirzad H, Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev med. 2014; 5: 1487-99.
50. Gulati OP, Berry OP. Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicology. 2006; 221: 75-87.
51. Nutraceuticals Market by Product and Geography - Forecast and Analysis2020-2025 by https://www.technavio.com/report/nutraceuticals-market-industry-analysis.
52. Brower B. Nutraceuticals: Poised for a healthy slice of the market. Nature Biotechnology. 1998; 16:728-33.
53. Mannion M. Nutraceutical revolution continues at Foundation for Innovation in Medicine Conference. American Journal of Natural Medicine. 1998;5:30-3.
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How to Cite
Ram Narayan Prajapati, and Sanjeev Kumar. “The Role, Scope, Health Benefits and Market Growth of Nutraceuticals: An Overview”. Current Research in Pharmaceutical Sciences, Vol. 10, no. 3, Mar. 2022, pp. 30-42, doi:10.24092/CRPS.2020.100301.
Section
Review Articles
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