Review on Diabetic Nephropathy

Narendra Singh Kushmakar; Abhilasha Jumnani

Narendra Singh Kushmakar Department of Pharmacology and ToxicologyBR Nahata college of Pharmacy (A SIRO Recognized by DSIR ministry of Science and technology, GOI) Mhow – Neemuch Road Mandsaur (M.P) 458001
Abhilasha Jumnani R.N.S. Institute of Pharmacy Sitholi Gwalior (M. P.)

Abstract

Diabetic nephropathy (DN) is one of the most frequent life threatening complications of diabetes
mellitus that occurs approximately 30-40%. It is usually attributed to metabolic consequences of
abnormal glucose regulations, such as elevated blood and tissue levels of glycosylated proteins and
hemodynamic changes within the kidney tissue. Recently there has been a renewed interest in
understanding the role of reactive oxygen species (ROS), which play a key intermediate role in the
pathophysiology of DN.

Keywords: diabetes mellitus, pathophysiology, Nephropathy, hyperglycaemia, anti oxidative mechanisms.

References

1. Sharma S, Kulkarni SK, Chopra K. Curcumin, The active principal of turmeric, ameliorates diabetic nephropathy in rates. Clin exp pharmacol 2006; 33: 940- 945.
2. Mclaughlin NG, Bhatt UY. Udayan. A review of the diagnosis and therapy of diabetic nephropathy.Northeast Florida Medicine Spring 2005; 27-32.
3. Vivian EM, Rubinstein GB. Pharmacologic management if Diabetic Nephropathy. Clinical Therapeutics. 2002; 24: 41-55.
4. Shumway TJ, Gambert RS. Diabetic nephropathy-pathophysiology and management. International Urology and Nephrology. 2002; 34:257-264.
5. Mclaughlin GN, Bhatt UY, Mars LR. A review of the diagnosis and therapy of Diabetic Nephropathy. Northeast Floroda Medicine 2005:27-31.
6. Fraser DJ, Phillips AO. Diabetic nephropathy. Medicine 2007; 35:503-506.
7. Watkins JP. ABC of Diabetes. 5th ed. BMJ Publishing Group Ltd, London 2003.