In Vitro Anticancer Activity of Gamma Oryzanol in Skin Cancer
Abstract
Plants have had an essential role in the folklore of ancient culture. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. Herbal products such as plant extracts, dry powder and parts of plants, fungi, and algae have been used as complementary treatments alongside conventional drugs. Cancer is a severe metabolic syndrome and is one of the leading causes of death regardless of developments in the tools of disease diagnosis, treatment and prevention measures. Cancer is one of the principal causes of mortality and morbidity around the globe and the number of cases are constantly increasing estimated to be 21 million by 2030. Several medicinal plant species and their phytochemicals inhibit the progression and development of cancer. In the present work In vitro anti cancer activity of gamma oryzanol was performed using SRB assay. Result shown that gamma oryzanol has anti cancer activity for SKMEL-2 cancerous cell line. On the basis of this result further study plan can be designed.
Keywords:
Cancer, Gamma oryzanol, Phytochemicals
References
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2. He L, Gu J, Lim LY, Yuan ZX, Mo J, Nanomedicine-mediated therapies to target breast cancer stem cells Front Pharmacol. 2016; 7:313.
3. Qin W, Huang G, Chen Z, Zhang Y, Nanomaterials in targeting cancer stem cells for cancer therapy Front Pharmacol. 2017;1.
4. Zhang LQ, Lv RW, Qu XD, Chen XJ, Lu HS, Wang Y, Aloesin suppresses cell growth and metastasis in ovarian cancer SKOV3 cells through the inhibition of the MAPK signaling pathway Anal Cell Pathol. 2017; 1-6.
5. American Cancer Society Cancer facts & figures, American Cancer Society, Atlanta, GA. 2016.
6. Siegel RL, Miller KD, Jemal A, Cancer statistics, 2016 CA Cancer J Clin, 2016; 66:1: 7-30.
7. Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RG, Barzi A, Colorectal cancer statistics. Cancer J Clin. 2017; 67:3:177-193.
8. Krishnamurthi K, 17-screening of natural products for anticancer and antidiabetic properties Cancer. 2007;3:4.
9. Horn L, Pao W, Johnson DH, Longo DL, Kasper DL, Jamson JL, Fauci AS, Hauser SL, Loscalzo J, Harrisons principles of internal medicine (18th ed.), MacGraw-Hill. New York. 2012.
10. Zhou Z, Tang M, Liu Y, Zhang Z, Lu R, Lu J, Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line Anti Cancer Drugs. 2017;28:4:446-456.
11. Kharb M, Jat RK, Gupta R, A review on medicinal plants used as a source of anticancer agents Int J Drug Res Technol. 2012;2:177-183.
12. Dixit S, Ali H, Anticancer activity of medicinal plant extract-a review J Chem Chem Sci. 2010;1:79-85.
13. Parkin D, Bray MF, Ferlay J, Pisani P, Global cancer statistics CA Cancer J Clin, 2015;5:74-108.
14. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN.Int J Cancer, 2015;136:E359-E386.
15. Faria SS, Morris CFM, Silva AR, Fonseca MP, Forget P, Castro MS, A timely shift from shotgun to targeted proteomics and how it can be groundbreaking for cancer research Front Oncol. 2017;7:13.
16. Thakore P, Mani RK, Kavitha SJ, A brief review of plants having anti-cancer property Int J Pharm Res Dev.2012;3:129-136.
17. Cragg GM, Newman DJ, Yang SS, Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience J Nat Prod.2016;69: 488-498.
18. Khan H, Medicinal plants in light of history: recognized therapeutic modality J Evid Based Complement Altern Med. 2014;19:216-219
19. Weaver BA, How taxol/paclitaxel kills cancer cells Mol Biol Cell. 2014; 25:18:2677-2681.
20. Singh S, Bhupender S, Kanwar SS, Kumar A, Lead phytochemicals for anticancer drug development Front Plant Sci. 2016;7:667.
21. Borlase W, The Natural History of Cornwall. E. & W. Books; Oxford. UK. 1758.
22. Ayoob I, Hazari YM, Lone SH, Khuroo MA, Fazili KM, Bhat KA, Phytochemical and cytotoxic evaluation of peganum harmala: structure activity relationship studies of harmine Chem Sel. 2017;10:2:2965-2968.
23. Skehan P, Storeng R, Scu- diero D, Monks A, McMohan J, Vistica D, Warren JT, Bokesh H, Kenny S & Boyd M, SRB ASSAY- New calorimetric cytotoxicity assay for anticancer drug screening J. Natl. Cancer Inst. 1990;82:1107-1111.
24. Vanicha V, Kanyawim K, Sulforhodamine B colorimetric assay for cytotoxicity screening Nature Protocols 2006;1:1112 – 1116.
25. Williams SD, Hughes TE, Adler CJ, Brook AH, Townsend GC. Epigenetics: a new frontier in dentistry. Australian Dent. J. 2014; 59(s1):23-33.
26. http://www.abcam.com/epigenetics/histone-modifications-a-guide.
27. Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell res. 2011; 21(3): 381.
28. Phillips T. Small non-coding RNA and gene expression. Nature Edu. 2008;1(1):115.
29. Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene. 2000; 19(1):164.
30. Riegert-Johnson, D. Peutz-Jeghers Syndrome. Intestinal Polyposis Syndromes. 2016; 117–164.
31. Kopacova M, Bures J, Ferko A, Tacheci I, Rejchrt S. Comparison of intraoperative enteroscopy and double-balloon enteroscopy for the diagnosis and treatment of Peutz-Jeghers Syndrome. Surg. Endosc. 2010; 24 (8): 1904–1910.
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How to Cite
Jainul Basher, Prabha Shankar Maurya, and Radheshyam. “In Vitro Anticancer Activity of Gamma Oryzanol in Skin Cancer ”. Current Research in Pharmaceutical Sciences, Vol. 12, no. 2, July 2022, pp. 105-7, doi:10.24092/CRPS.2022.120205.
Section
Research Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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