Current Research in Pharmaceutical Sciences

Techniques and Evaluation Tests for Colon Cancer Treatment Using Pellets: A Review

Shubham M. Waghmare — 2024-03-02

This review outlines the manufacturing process for globular pellets. The production method includes the following steps: drug stacking, displacement-merumerization, cryopelletization, shrink, balling, hot-soften extrusion generation, freeze pelletization, spray-drying, and spray-congealing. The benefits and risks of several pelletization methods were discussed. The current study's objective is to examine the efficacy of anticancer drugs and metal chelators in treating colorectal cancer (CRC). Phytic acid, 5-fluorouracil (5-FU), microcrystalline cellulose (MCC) PH 100 and 1 compile in the pellets, hydroxypropyl methylcellulose (HPMC), and barium sulphate were processed utilizing the extrusion spheronization technology. To achieve colon-specific medication delivery, Eudragit S100 was layered over the ability pellets. Pellets have been praised for a variety of micromeritic and medicinal qualities. In the Ehrlich ascites carcinoma (EAC)-driven patient-derived zenograft (PDX) paradigm, the in vivo treatment potency separates the pharmacokinetic and pharmacodynamic bounds. By chelating manganese, phytic acid, and five-FU combinations, they appear to provide more cytotoxic interest through a better reactive oxygen species (ROS) stage. Later pharmacokinetic studies showed a maximum 50% drop in Cmax within the finished setup, indicating decreased inherent exposure to the drug component.

Eco-Friendly Method Development and Validation for the Estimation of Fenofibrate and Atorvastatin in Marketed Formulation

Irshad Ali — 2024-03-02

This study focuses on the development and validation of an eco-friendly analytical method for the simultaneous estimation of Fenofibrate (FNF) and Atorvastatin (ATV) in a marketed formulation. The stability of both drugs was evaluated using a mixed hydrotropic solution of 2M Ammonium Acetate and 2M Sodium Citrate (1:1). This work focuses on the development and validation of an eco-friendly method for the simultaneous estimation of Fenofibrate and Atorvastatin in a marketed formulation. The stability of both drugs in a mixed hydrotropic solution was confirmed, and the method exhibited good linearity, recovery, and precision. The validated method was successfully applied to analyze a tablet formulation, demonstrating its applicability in routine quality control. The use of environmentally friendly practices in analytical methods contributes to sustainable pharmaceutical analysis.

Evaluation of in vivo Anti-acne Activity of Flower Extract of Withania coagulans

Rani Jatav — 2024-03-02

Acne vulgaris is the widespread chronic skin illness. Conventional therapy has drawbacks, such as increasing antibiotic resistance in the microorganisms that cause acne. Herbs are a natural medicine source that has negligible to no adverse effects when used to treat acne. Numerous researches are carried out to help teens and other individuals avoid acne. Thus, this study deals with discovering the anti-acne potential of medicinal plants W. coagulans. Initially gathering of plant flowers, its extraction and qualitative and quantitative analysis was performed. The in vivo anti-acne activity was performed by inducing the heat killed P. acne in rats’ ear and measuring its thickness on specific days. The results showed that plant contains the alkaloid, flavonoid, phenol, protein, carbohydrate, saponin, diterpene, tannin. Total flavonoids content and Total phenol content were found to be0.67 and 0.95 mg/ 100 mg of dried extract of Withania coagulans respectively. In animal mode, at the end of 10th day the ear thickness in Withania coagulans 200 mg/kg treated rats was observed to be 0.19±0.05 which is near to ear thickness of 0.10±0.03 observed in Clindamycin 200 mg/kg p.o treated rats. The results of the extracts were comparable with standard. The data resulted from anti-acne effect of hydroalcoholic extract of Withania coagulans was significantly decreased the inflammation in rat’s ear. Thus, it can be concluded that that Withania coagulans had appreciable anti-acne activity. Withania coagulans can thus be utilized to develop antiacne formulations and tested in preclinical and clinical studies due to its good potency against bacteria that cause acne.

Sustainable Green Analytical Chemistry: Spectrophotometric Method Development of Dapagliflozin and Omeprazole by Using Eco-friendly Solvent

Sakshi A. Jadhav — 2024-03-02

The present research’s aim was to develop analytical method utilizing ecologically suitable solvent which enhances solubility of analyte, sensitivity of the method etc. An analytical method was developed for the estimation of dapagliflozin (DGZ) and omeprazole (OPZ) by using aqueous 0.1 N HCl on the UV-VIS spectrophotometer. Wavelengths 223 nm and 282.5 nm were set to measure absorbance of DGZ and OPZ respectively. The results of different spectral characteristic techniques were examined to select the parameters and the design was validated against the ICH Q 2 R1 regulatory guidelines. The linearity of the drug was determined at a concentration of 1 to 50μg/ml and 1 to 32μg/ml for DGZ and OPZ respectively. The accuracy was found within acceptable limit with standard deviation 1.1874 to 6.4984 for DGZ and 0.1401 to 0.9843 for OPZ; and the assay study data was found 99.77 % for DGZ and 97.92 % for OPZ. The stability study of the method was performed out by minute variation in the wavelength, scan speed. The developed method is rigid, robust and efficient for the estimation of DGZ and OPZ from their respective dosage form. The effort was made to develop green or eco-friendly analytical method utilizing hydrotropic solvent for water insoluble drug dapagliflozin and omeprazole.