Fast Dissolving Oral Film: An Innovative Approach for Drug Delivery
Abstract
The present review will provide an overview of orally fast dissolving films. The most popular oral dosage forms are oral fast-dissolving films, which dissolve in the mouth in a matter of seconds without the need for water consumption and provide a quick onset of action. Because of their flexibility and ability to comply with patients, these drug delivery systems are primarily used for pediatric and geriatric patients. They release the active pharmaceutical ingredient within the mouth as soon as they come into contact with saliva. A rapidly dissolving oral dosage form that can be used for drugs with low bioavailability and high first pass metabolism. Oral films are formulated using polymers, plasticizers, colors, flavors and sweeteners etc. Solvent casting, hot melt extrusion, rolling, and solid dispersion techniques are used in the production of the oral film. This review compiles the most recent developments in the formulation of fast-dissolving films and their evaluation metrics, such as thickness, disintegration time, folding endurance, and in-vitro dissolution. It also highlights some of the marketed products to demonstrate the market's demand for oral fast-dissolving films. Also, go over a few of the difficulties encountered during the creation of fast-dissolving films.
Keywords:
Fast dissolving film, Solvent casting method, film forming polymer, Evaluation
References
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2. Siddiqui, M.N., Garg, G. and Sharma, P.K., 2011. A short review on “A novel approach in oral fast dissolving drug delivery system and their patents”. Advanced Biology Research, 5(6), pp.291-303.
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8. Arya, A., Chandra, A., Sharma, V. and Pathak, K., 2010. Fast dissolving oral films: an innovative drug delivery system and dosage form. International Journal of ChemTech Research, 2(1), pp.576-583.
9. Barnhart, S.D and Sloboda, M.S., 2007. The future of dissolvable films. Drug Delivery Technology, 7(8), pp.34-7.
10. Garg, R.,Singh, R., Sharma, D. and 2017. Review on mucoadhesive drug delivery system with special emphasis on buccal route: an important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals. Journal of Delivering Drug, 6(01), pp.1-12.
11. Kathpalia, H. and Gupte, A., 2013. An introduction to fast dissolving oral thin film drug delivery systems: a review. Current Drug Delivery, 10(6), pp.667-684.
12. Kundu, S. and Sahoo, P.K., 2008. Recent trends in the developments of orally disintegrating tablet technology. Pharma Times, 40(4), pp.11-15.
13. Wasilewska, K. and Winnicka, K., 2019. How to assess orodispersible film quality A review of applied methods and their modifications. Acta Pharmaceutica, 69(2), pp.155-176.
14. Chauhan, I., Yasir, M., Nagar, P., 2012. Insights into polymers: film formers in mouth dissolving films. Drug Invent. Today 3, 56–73.
15. Nagar, P., Chauhan, I. and Yasir, M., 2011. Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug invention today, 3(12).
16. Hutteau, F., Mathlouthi, M., Portmann, M.O. and Kilcast, D., 1998. Physicochemical and psychophysical characteristics of binary mixtures of bulk and intense sweeteners. Food Chemistry, 63(1), pp.9-16.
17. Visser, M.R., Baert, L., van’t Klooster, G., Schueller, L., Geldof, M., Vanwelkenhuysen, I., De Kock, H., De Meyer, S., Frijlink, H.W., Rosier, J. and Hinrichs, W.L., 2010. Inulin solid dispersion technology to improve the absorption of the BCS Class IV drug TMC240. European journal of pharmaceutics and biopharmaceutics, 74(2), pp.233-238.
18. Sohi, H., Sultana, Y. and Khar, R.K., 2004. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug development and industrial pharmacy, 30(5), pp.429-448.
19. Khairnar, A., Jain, P., Baviskar, D. and Jain, D., 2009. Development of mucoadhesive buccal patch containing aceclofenac: in-vitro evaluations. International Journal of Pharmaceutical TechnologyResearch, 1(4), pp.978-81.
20. Reza, K.H. and Chakraborty, P., 2016. Recent industrial development in oral thin film technology: An overview. PharmaTutor, 4(8), pp.17-22.
21. Shinde, A.J., Garala, K.C. and More, H.N., 2008. Development and characterization of transdermal therapeutics system of tramadol hydrochloride. Asian Journal of Pharmaceutics, 2(4).
22. Chokshi, R. and Zia, H., 2004. Hot-melt extrusion technique: a review. Iranian journal of pharmaceutical research, 3(1), pp.3-16.
23. Sharma, D., Kaur, D., Verma, S., Singh, D., Singh, M., Singh, G. and Garg, R., 2015. Fast dissolving oral films technology: A recent trend for an innovative oral drug delivery system. International Journal of Drug Delivery, 7(2), pp.60-75.
24. Sharma, P.K., Sharma, P.K., Darwhekar, G.N. and Shrivastava, B., 2018. An overview about novel fast dissolving oral films. International Journal of Drug Regulatory Affairs (IJDRA), 6(1), pp.1-7.
25. Cilurzo, F., Cupone, I.E., Minghetti, P., Selmin, F. and Montanari, L., 2008. Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 70(3), pp.895-900.
26. Karki, S., Kim, H., Na, S.J., Shin, D., Jo, K. and Lee, J., 2016. Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences, 11(5), pp.559-574.
27. Vishwkarma, D.K., Tripathi, A.K., Yogesh, P. and Maddheshiya, B., 2011. Review article on mouth dissolving film. Journal of global pharma Technology, 3(1), pp.1-8.
28. Hariharan, M., 2009. Orally dissolving film strips (ODFS): the final evolution of orally dissolving dosage forms. Drug Delivery, Technology, 9, pp.24-29.
29. Sastry, S.V., Degennaro, M.D., Reddy, L.K. and Khan, M.A., 1997. Atenolol gastrointestinal therapeutic system. I. Screening of formulation variables. Drug development and industrial pharmacy, 23(2), pp.157-165.
30. Kundu, S. and Sahoo, P.K., 2008. Recent trends in the developments of orally disintegrating tablet technology. Pharma Times, 40(4), pp.11-15.
2. Siddiqui, M.N., Garg, G. and Sharma, P.K., 2011. A short review on “A novel approach in oral fast dissolving drug delivery system and their patents”. Advanced Biology Research, 5(6), pp.291-303.
3. Gandhi,S.D., Pandya, P.R., Umbarkar, R., Tambawala, T. and Shah, M.A., 2011. Mucoadhesive drug delivery systems-An unusual maneuver for site specific drug delivery system. International Journal of Research in Biological Sciences, 2(3), pp.132-52.
4. Bhura, N., Sanghvi, K., Patel, U. and parmar, B., 2012. A review on fast dissolving film. The International Journal of Pharmaceutical Research and Bio-Science, 1(3).
5. Pawar, R., Sharma, R., Sharma, P. and Darwhekar, G.N., 2019. A review on mouth dissolving film. Journal of Drug delivery and Therapeutics, 9(6), pp.206-210.
6. Bhyan, B., Jangra, S., Kaur, M. and Singh, H., 2011. Orally fast dissolving films: innovations in formulation and technology. International Journal of Pharmaceutical Science Review Research, 9(2), pp.9-15.
7. Pawar, P., Bala, R., Khanna, S. and Arora, S., 2013. Orally dissolving strips: A new approach to oral drug delivery system. International Journal of Pharmaceutical Investigation, 3(2), p.67.
8. Arya, A., Chandra, A., Sharma, V. and Pathak, K., 2010. Fast dissolving oral films: an innovative drug delivery system and dosage form. International Journal of ChemTech Research, 2(1), pp.576-583.
9. Barnhart, S.D and Sloboda, M.S., 2007. The future of dissolvable films. Drug Delivery Technology, 7(8), pp.34-7.
10. Garg, R.,Singh, R., Sharma, D. and 2017. Review on mucoadhesive drug delivery system with special emphasis on buccal route: an important tool in designing of novel controlled drug delivery system for the effective delivery of pharmaceuticals. Journal of Delivering Drug, 6(01), pp.1-12.
11. Kathpalia, H. and Gupte, A., 2013. An introduction to fast dissolving oral thin film drug delivery systems: a review. Current Drug Delivery, 10(6), pp.667-684.
12. Kundu, S. and Sahoo, P.K., 2008. Recent trends in the developments of orally disintegrating tablet technology. Pharma Times, 40(4), pp.11-15.
13. Wasilewska, K. and Winnicka, K., 2019. How to assess orodispersible film quality A review of applied methods and their modifications. Acta Pharmaceutica, 69(2), pp.155-176.
14. Chauhan, I., Yasir, M., Nagar, P., 2012. Insights into polymers: film formers in mouth dissolving films. Drug Invent. Today 3, 56–73.
15. Nagar, P., Chauhan, I. and Yasir, M., 2011. Insights into Polymers: Film Formers in Mouth Dissolving Films. Drug invention today, 3(12).
16. Hutteau, F., Mathlouthi, M., Portmann, M.O. and Kilcast, D., 1998. Physicochemical and psychophysical characteristics of binary mixtures of bulk and intense sweeteners. Food Chemistry, 63(1), pp.9-16.
17. Visser, M.R., Baert, L., van’t Klooster, G., Schueller, L., Geldof, M., Vanwelkenhuysen, I., De Kock, H., De Meyer, S., Frijlink, H.W., Rosier, J. and Hinrichs, W.L., 2010. Inulin solid dispersion technology to improve the absorption of the BCS Class IV drug TMC240. European journal of pharmaceutics and biopharmaceutics, 74(2), pp.233-238.
18. Sohi, H., Sultana, Y. and Khar, R.K., 2004. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug development and industrial pharmacy, 30(5), pp.429-448.
19. Khairnar, A., Jain, P., Baviskar, D. and Jain, D., 2009. Development of mucoadhesive buccal patch containing aceclofenac: in-vitro evaluations. International Journal of Pharmaceutical TechnologyResearch, 1(4), pp.978-81.
20. Reza, K.H. and Chakraborty, P., 2016. Recent industrial development in oral thin film technology: An overview. PharmaTutor, 4(8), pp.17-22.
21. Shinde, A.J., Garala, K.C. and More, H.N., 2008. Development and characterization of transdermal therapeutics system of tramadol hydrochloride. Asian Journal of Pharmaceutics, 2(4).
22. Chokshi, R. and Zia, H., 2004. Hot-melt extrusion technique: a review. Iranian journal of pharmaceutical research, 3(1), pp.3-16.
23. Sharma, D., Kaur, D., Verma, S., Singh, D., Singh, M., Singh, G. and Garg, R., 2015. Fast dissolving oral films technology: A recent trend for an innovative oral drug delivery system. International Journal of Drug Delivery, 7(2), pp.60-75.
24. Sharma, P.K., Sharma, P.K., Darwhekar, G.N. and Shrivastava, B., 2018. An overview about novel fast dissolving oral films. International Journal of Drug Regulatory Affairs (IJDRA), 6(1), pp.1-7.
25. Cilurzo, F., Cupone, I.E., Minghetti, P., Selmin, F. and Montanari, L., 2008. Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 70(3), pp.895-900.
26. Karki, S., Kim, H., Na, S.J., Shin, D., Jo, K. and Lee, J., 2016. Thin films as an emerging platform for drug delivery. Asian Journal of Pharmaceutical Sciences, 11(5), pp.559-574.
27. Vishwkarma, D.K., Tripathi, A.K., Yogesh, P. and Maddheshiya, B., 2011. Review article on mouth dissolving film. Journal of global pharma Technology, 3(1), pp.1-8.
28. Hariharan, M., 2009. Orally dissolving film strips (ODFS): the final evolution of orally dissolving dosage forms. Drug Delivery, Technology, 9, pp.24-29.
29. Sastry, S.V., Degennaro, M.D., Reddy, L.K. and Khan, M.A., 1997. Atenolol gastrointestinal therapeutic system. I. Screening of formulation variables. Drug development and industrial pharmacy, 23(2), pp.157-165.
30. Kundu, S. and Sahoo, P.K., 2008. Recent trends in the developments of orally disintegrating tablet technology. Pharma Times, 40(4), pp.11-15.
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How to Cite
Kuldeep Chaturvedi, Pravin Kumar Sharma, Sumeet Dwivedi, Ravi Sharma, and Gajanan N. Darwhekar. “Fast Dissolving Oral Film: An Innovative Approach for Drug Delivery ”. Current Research in Pharmaceutical Sciences, Apr. 2024, pp. 01-09, doi:10.24092/CRPS.2024.140101.
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Review Articles
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