Formulation and Evaluation of Solid Dispersion of Chrysin for Improved Bioavailability

  • Devraj Pandey Lakshmi Narain College of Pharmacy, Bhopal, India 462001
  • Kajal Sharma Lakshmi Narain College of Pharmacy, Bhopal, India 462001
  • Parulben D Mehta Lakshmi Narain College of Pharmacy, Bhopal, India 462001

Abstract

The objective of the present study was to prepared solid dispersion of chrysin for improving its aqueous solubility and in turn its oral bioavailability. I-opitmal design approach was used for preparing the solid dispersion of chrysin. A total of eight formulations were prepared using four different ratios of drug to carrier. Mannitol and PVP-K30 were used as the two different carriers to improve the solubility of chrysin by formulating SD using solvent evaporation method employing ethanol as the common solvent for the drug and the carrier. The solubility study of chrysin was performed in distilled water and was found to be 3.7 µg/mL. The particles were irregular to spherical in shape and the average particle size ranged from 34.90-38.09 µm for the particles. The yield of the SD was highest for F5 (93.2%) and least for F8 (91.14%). For all the formulations the yield was nevertheless higher than 90% suggesting a proper binary mixture formation. The drug content was found to be highest in the formulation SD4 (94.23 ± 0.351 %) and the lowest in formulation SD5 (91.18 ± 0.251 %).

Keywords: Solid dispersion, chrysin, mannitol, PVP K30, solvent evaporation

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How to Cite
Devraj Pandey, Kajal Sharma, and Parulben D Mehta. “Formulation and Evaluation of Solid Dispersion of Chrysin for Improved Bioavailability”. Current Research in Pharmaceutical Sciences, Vol. 13, no. 3, Dec. 2023, pp. 145-50, doi:10.24092/CRPS.2023.130305.
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Research Articles