Development and Characterization of Gamma Oryzanol Loaded Niosomes

  • Shubham Sharma Faculty of Pharmacy, Bhagwant University, Ajmer, India 305001
  • Budhram Saharan Faculty of Pharmacy, Bhagwant University, Ajmer, India 305001
  • Jinendra Sardiya Institute of Pharmaceutical Sciences, SAGE University, Indore, India 452001
  • Vishvas Pathak Institute of Pharmaceutical Sciences, SAGE University, Indore, India 452001

Abstract

Over the past several years, treatment of infectious diseases and immunization has undergone a revolutionary shift. Noisome are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. Noisome are of nonionic multilamellar vesicular structure of surface-active agents, which is similar to liposomes. This article highlights Ƴ-oryzanol (Oz) exert their antioxidant activity and often associated with lowering level of cholesterol, anti-inflammatory, anti-diabetic and anti-cancer effects. All reformulation studies were performed. The thin-film hydration technique was used for encapsulation of OZ in noisome. More than 85 % entrapment of Oz was achieved. Nearly 90 % drug was released within 24 hours. Formulation was found sterilized. Formulation was found stable after 5 weeks.

Keywords: Niosomes, Gamma Oryzanol, Liposomes, Antioxidant

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How to Cite
Shubham Sharma, Budhram Saharan, Jinendra Sardiya, and Vishvas Pathak. “Development and Characterization of Gamma Oryzanol Loaded Niosomes”. Current Research in Pharmaceutical Sciences, Vol. 13, no. 3, Dec. 2023, pp. 133-5, doi:10.24092/CRPS.2023.130303.
Section
Research Articles