A Comprehensive Review on Pharmacological Properties of Garden cress (Lepidium sativum) Seeds
Abstract
The present article gives important information of Lepidium sativum on therapeutic use, traditional medicinal uses mantion in various Ayurvedic literecture, phytochemical and pharmacological properties of morden era. Lepidium sativum, garden cress is a fast growing annual herb that is native to Egypt and West Asia, although it is now cultivated in the entire world. Lepidium sativum seeds contain proteins, dietary fiber, omega-3 fatty acids, iron, other essential nutrients and phytochemicals. Lepidium sativum seeds are commonly used to heal fractures and to increase milk secretion during lactation. Their seeds are highly nutritious and are excellent source of iron. It is mainly contains alkaloids, carbohydrates, proteins, amino acids, flavonoids as chief phytochemical constituents.
This review article shows various pharmacological activities of Lepidium sativum as an anti-diabetic, laxative, hypocholesterolemic, fracture healing, analgesic, Antinflammatory, antipyretic and analgesic, laxative, diuretic, hepatoprotective, antiashthamatic, antidiarrheal, antispasmodic and anti cancer activities of garden cress seeds (Lepidium sativum).
Keywords:
Lepidium sativum, Garden cress, pharmacological activities
References
1. Nadkarni KM, Nadkarni AK. In: The Indian Materia Medica with Ayurvedic, Unani and Home remedies, 3rd edn. Popular Prakashan, Bombay, India. 1954: 736–737.
2. Nuez F, Hernandez JE. Plant Production and Protection Series No. 26, Rome, Italy. 1994: 303–332.
3. Nadkarni KM. Indian Materia Medica, Popular Prakashan,Bombay, India: 1976.
4. Kumar AD. Ayurvedic Drug Plants, Publisher: Daya Books, 2006: 97.
5. Gigi Elizabeth KG and Poojara RH. Organoleptic attributes of Garden Cress Seed incorporated snacks suitable for adolescents. International Journal of Food and Nutritional science. 2014; 3(6): 126-129.
6. Gokavi SS, Mallesh NG, Guo M. Chemical composition of garden cress (Lepidium sativum) seeds and its fractions and use of bran as a functional ingredient. Plant Foods Hum Nutr. 2004; 59: 105-111.
7. Shail et al. Nutritional importance of Lepidium sativum L. (Garden cress/ Chandrashoor): A Review. Int. J. of Pharmacy and Analytical Research. 2016; 5(1): 152-160.
8. Arkroyd WR, Gopalan C, Balasubramanian SC. Nutritive value of Indian Foods and the planning of satisfactory diets. Indian Council of Medical Research, New Delhi, 1960: 64.
9. Mathews S, Singhal RS, Kulkarni PR. Some physicochemical properties of Lepidium sativum (Haliv) seed. Die Nahrung. 1993; 37: 69-71.
10. Vohora SB, Khan MSY. Pharmacological studies on Lepidium sativum Linn. Indian J Physiol Pharmac. 1977; 21:118-120.
11. Anonymous. The Wealth of Indian Raw Materials Publication and information Directorate, CSIR, New Delhi, 1972; 9:71-72.
12. Kirtkar KM, Basu BD. Indian medicinal Plants. 2005; I: 174.
13. Dannehl D et al. Influence of intermittent-direct-electriccurrent (IDC) on phytochemical compounds in garden cress during growth. Food Chem. 2012; 131:239-246.
14. Mandal K, Patel PR and Maiti S. Australasian Plant Disease Notes. 2008: 373‐74.
15. Singh R et al. Acceptability evaluation of iron rich product developed from Lepidium sativum. International Journal of Recent Advances in Multidisciplinary Research. 2017; 04 (06): 2629-2631.
16. Anonymous. Ayurvedic Pharmacopoeia of India, Part- 1,1st ed, The drug controller of India, Government of India, Ministry of health and family welfare development of Indian system of medicine and homeopathy, New Delhi civil lines, Delhi. 2001; 1:26.
17. Bigoniya P, Singh CS, Shukla A. Pharmacognostical and physicochemical standardization of ethnopharmacologically important seeds of Lepidium sativum Linn. and Wrightia tinctoria R. Br. Indian Journal of Natural Products and Resources. 2011; 2(4):464-471.
18. Zia-Ul-Haq M. et al. Compositional Study and Antioxidant Potential of Ipomoea hederacea Jacq. And Lepidium sativum L. Seed. Molecules. 2012; 17:10306-10321.
19. Ulrich HM, Heidrun G, Meinhart HZ. Seven Imidazole alkaloids from Lepidium sativum. Phytochem.1998; 49: 1791 -1795.
20. Ali M, Rumman A. Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Extracted Oil from Whole Garden Cress (Rashaad) Seeds. American journal of engineering research. 2018; 7(4): 01 -08.
21. Radwan et al. Investigation of the Glucosinolates of Lepidium sativum Growing in Egypt and their Biological activity. Res J Med Sci 2007; 2(2):127-132.
22. Eddoaks M, Maghrani M, Zeggwagh NA, Michel JB. Study of the hypoglycemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats. J Ethnopharmacol 2005; 97: 391-395.
23. Abdullah H, Abdullah J. The Effects of Lepidium sativum Seeds on Fracture-Induced Healing in Rabbits. Med Gen Med. 2007; 9(2): 23 -29.
24. Wafeka A, Al H. Protective Effect of Lepidium sativum L. Seeds Powder and Extract on Hypercholesterolemic Rats. J American Sci. 2010; 6(11): 873-879.
25. Manohar D, Shylaja H, Viswanatha GL, Rajesh S. Antidiarrheal activity of methanolic extracts of Lepidium sativum in rodent. J Nat Remidies. 2009; 9 (2): 197-201.
26. Chand Y et al. In vivo antioxidant potential of Lepidium sativum L. seeds in albino rats using cisplatin induced nephrotoxicity. Inter J. Phytomed. 2010; 2: 292-298.
27. Najeeb UR et al. Prokinetic and laxative activities of Lepidium sativum seed extract with species and tissue selective gut stimulatory actions. J Ethanopharmacol. 2011; 134: 878-883.
28. Raval ND, Pandya TN. Clinical trial of Lepidium Sativum Linn(Chandrashura) in the management of Sandhivata(Osteoarthritis) I.P.G.T. & R.A, Gujarat Ayurved University, Jamnagar. Ayu., 2009; 30(2): 153-157.
29. Patel U, Kulkarni M, Undale V and Bhosale A. Evaluation of Diuretic Activity of Aqueous and Methanol Extracts of Lepidium sativum Garden Cress (Cruciferae) in Rats. Tropical Journal of Pharmaceutical Research, 2009; 8 (3): 215-219.
30. Naji NS. Changes in sperm parameters of adult male rabbits by phenol extract of Lepidium sativum seeds. Journal of Natural Sciences Research.2013; 3(8): 17-22.
31. Al-Yahya MA et al. Pharmacological and safety evaluation studies on Lepidium sativum L. seeds. Phytomedicine.1994; 1: 155-9.
32. Adam SE. Effects of various levels of dietary Lepidium sativum Linn. in rats. The American Journal of Chinese Medicine. 1999; 27: 397-405.
33. Paranjape AN, Mehta AA. A Study on Clinical Efficacy of Lepidium Sativum Seeds in Treatment of Bronchial Asthma. Iranian Journal of Pharmacology & Therapeutics. 2006; 5(1):55-59.
34. Adam, SIY, Salih SAM, Abdelgadir WS. In vitro Antimicrobial Assessment of Lepidiumsativum L. Seeds Extracts. Asian Journal of Medical Sciences. 2011; 3(6):261-266.
35. Sharma RK, Vyas K, Manda H. Evaluation of antifungal effect on ethanolic extract of lepidium sativum L. Seed. International Journal of Phytopharmacology. 2012; 3(2):117-120.
36. Mahassni SH, Al-Reemi RM. Cytotoxic effect of an aqueous extract of lepidium sativum L. Seed on human breast cancer cells. Indian Journal of Traditional Knowledge. 2013; 12(4):605-614.
37. Yadav YC, Srivastav DN, Seth AK, Gupta VD, Yadav KS, Kumar S. Nephroprotective and curative activity of Lepidium sativum L. seeds in albino rats using cisplatin induced Nephrotoxicity.Pharmacologyonline.2009; 3: 640-646.
38. Al-Yawer MA, Al-Khateeb HM. Garden Cress Seed Could be A Factual Galactagogue. The Iraqi Postgraduate Medical Journal, 2006; 5(1):62-67.
39. Abuelgasim A, Nuha HS, Mohammed AH. Hepatoprotective effect of lepidium sativum against carbon tetrachloride induced damage in rats. Research Journal of Animal and Veterinary Sciences. 2008; 3: 20-23.
40. Doke S and Guha M. Garden cress (Lepidium sativum L.) Seed - An Important Medicinal Source: A Review. J. Nat. Prod. Plant Resour.2014; 4(1):69-80.
2. Nuez F, Hernandez JE. Plant Production and Protection Series No. 26, Rome, Italy. 1994: 303–332.
3. Nadkarni KM. Indian Materia Medica, Popular Prakashan,Bombay, India: 1976.
4. Kumar AD. Ayurvedic Drug Plants, Publisher: Daya Books, 2006: 97.
5. Gigi Elizabeth KG and Poojara RH. Organoleptic attributes of Garden Cress Seed incorporated snacks suitable for adolescents. International Journal of Food and Nutritional science. 2014; 3(6): 126-129.
6. Gokavi SS, Mallesh NG, Guo M. Chemical composition of garden cress (Lepidium sativum) seeds and its fractions and use of bran as a functional ingredient. Plant Foods Hum Nutr. 2004; 59: 105-111.
7. Shail et al. Nutritional importance of Lepidium sativum L. (Garden cress/ Chandrashoor): A Review. Int. J. of Pharmacy and Analytical Research. 2016; 5(1): 152-160.
8. Arkroyd WR, Gopalan C, Balasubramanian SC. Nutritive value of Indian Foods and the planning of satisfactory diets. Indian Council of Medical Research, New Delhi, 1960: 64.
9. Mathews S, Singhal RS, Kulkarni PR. Some physicochemical properties of Lepidium sativum (Haliv) seed. Die Nahrung. 1993; 37: 69-71.
10. Vohora SB, Khan MSY. Pharmacological studies on Lepidium sativum Linn. Indian J Physiol Pharmac. 1977; 21:118-120.
11. Anonymous. The Wealth of Indian Raw Materials Publication and information Directorate, CSIR, New Delhi, 1972; 9:71-72.
12. Kirtkar KM, Basu BD. Indian medicinal Plants. 2005; I: 174.
13. Dannehl D et al. Influence of intermittent-direct-electriccurrent (IDC) on phytochemical compounds in garden cress during growth. Food Chem. 2012; 131:239-246.
14. Mandal K, Patel PR and Maiti S. Australasian Plant Disease Notes. 2008: 373‐74.
15. Singh R et al. Acceptability evaluation of iron rich product developed from Lepidium sativum. International Journal of Recent Advances in Multidisciplinary Research. 2017; 04 (06): 2629-2631.
16. Anonymous. Ayurvedic Pharmacopoeia of India, Part- 1,1st ed, The drug controller of India, Government of India, Ministry of health and family welfare development of Indian system of medicine and homeopathy, New Delhi civil lines, Delhi. 2001; 1:26.
17. Bigoniya P, Singh CS, Shukla A. Pharmacognostical and physicochemical standardization of ethnopharmacologically important seeds of Lepidium sativum Linn. and Wrightia tinctoria R. Br. Indian Journal of Natural Products and Resources. 2011; 2(4):464-471.
18. Zia-Ul-Haq M. et al. Compositional Study and Antioxidant Potential of Ipomoea hederacea Jacq. And Lepidium sativum L. Seed. Molecules. 2012; 17:10306-10321.
19. Ulrich HM, Heidrun G, Meinhart HZ. Seven Imidazole alkaloids from Lepidium sativum. Phytochem.1998; 49: 1791 -1795.
20. Ali M, Rumman A. Gas Chromatography-Mass Spectrometry (GC-MS) Analysis of Extracted Oil from Whole Garden Cress (Rashaad) Seeds. American journal of engineering research. 2018; 7(4): 01 -08.
21. Radwan et al. Investigation of the Glucosinolates of Lepidium sativum Growing in Egypt and their Biological activity. Res J Med Sci 2007; 2(2):127-132.
22. Eddoaks M, Maghrani M, Zeggwagh NA, Michel JB. Study of the hypoglycemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats. J Ethnopharmacol 2005; 97: 391-395.
23. Abdullah H, Abdullah J. The Effects of Lepidium sativum Seeds on Fracture-Induced Healing in Rabbits. Med Gen Med. 2007; 9(2): 23 -29.
24. Wafeka A, Al H. Protective Effect of Lepidium sativum L. Seeds Powder and Extract on Hypercholesterolemic Rats. J American Sci. 2010; 6(11): 873-879.
25. Manohar D, Shylaja H, Viswanatha GL, Rajesh S. Antidiarrheal activity of methanolic extracts of Lepidium sativum in rodent. J Nat Remidies. 2009; 9 (2): 197-201.
26. Chand Y et al. In vivo antioxidant potential of Lepidium sativum L. seeds in albino rats using cisplatin induced nephrotoxicity. Inter J. Phytomed. 2010; 2: 292-298.
27. Najeeb UR et al. Prokinetic and laxative activities of Lepidium sativum seed extract with species and tissue selective gut stimulatory actions. J Ethanopharmacol. 2011; 134: 878-883.
28. Raval ND, Pandya TN. Clinical trial of Lepidium Sativum Linn(Chandrashura) in the management of Sandhivata(Osteoarthritis) I.P.G.T. & R.A, Gujarat Ayurved University, Jamnagar. Ayu., 2009; 30(2): 153-157.
29. Patel U, Kulkarni M, Undale V and Bhosale A. Evaluation of Diuretic Activity of Aqueous and Methanol Extracts of Lepidium sativum Garden Cress (Cruciferae) in Rats. Tropical Journal of Pharmaceutical Research, 2009; 8 (3): 215-219.
30. Naji NS. Changes in sperm parameters of adult male rabbits by phenol extract of Lepidium sativum seeds. Journal of Natural Sciences Research.2013; 3(8): 17-22.
31. Al-Yahya MA et al. Pharmacological and safety evaluation studies on Lepidium sativum L. seeds. Phytomedicine.1994; 1: 155-9.
32. Adam SE. Effects of various levels of dietary Lepidium sativum Linn. in rats. The American Journal of Chinese Medicine. 1999; 27: 397-405.
33. Paranjape AN, Mehta AA. A Study on Clinical Efficacy of Lepidium Sativum Seeds in Treatment of Bronchial Asthma. Iranian Journal of Pharmacology & Therapeutics. 2006; 5(1):55-59.
34. Adam, SIY, Salih SAM, Abdelgadir WS. In vitro Antimicrobial Assessment of Lepidiumsativum L. Seeds Extracts. Asian Journal of Medical Sciences. 2011; 3(6):261-266.
35. Sharma RK, Vyas K, Manda H. Evaluation of antifungal effect on ethanolic extract of lepidium sativum L. Seed. International Journal of Phytopharmacology. 2012; 3(2):117-120.
36. Mahassni SH, Al-Reemi RM. Cytotoxic effect of an aqueous extract of lepidium sativum L. Seed on human breast cancer cells. Indian Journal of Traditional Knowledge. 2013; 12(4):605-614.
37. Yadav YC, Srivastav DN, Seth AK, Gupta VD, Yadav KS, Kumar S. Nephroprotective and curative activity of Lepidium sativum L. seeds in albino rats using cisplatin induced Nephrotoxicity.Pharmacologyonline.2009; 3: 640-646.
38. Al-Yawer MA, Al-Khateeb HM. Garden Cress Seed Could be A Factual Galactagogue. The Iraqi Postgraduate Medical Journal, 2006; 5(1):62-67.
39. Abuelgasim A, Nuha HS, Mohammed AH. Hepatoprotective effect of lepidium sativum against carbon tetrachloride induced damage in rats. Research Journal of Animal and Veterinary Sciences. 2008; 3: 20-23.
40. Doke S and Guha M. Garden cress (Lepidium sativum L.) Seed - An Important Medicinal Source: A Review. J. Nat. Prod. Plant Resour.2014; 4(1):69-80.
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How to Cite
Alok Sharma. “A Comprehensive Review on Pharmacological Properties of Garden Cress (Lepidium Sativum) Seeds ”. Current Research in Pharmaceutical Sciences, Vol. 10, no. 2, Aug. 2020, pp. 13-18, doi:10.24092/CRPS.2020.100201.
Section
Review Articles
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