New Spectrophotometric Method for the Estimation of Naproxen in Tablets using N, N- di methyl urea as Hydrotropic Agent

  • Mahendra Patel Rishiraj College of Pharmacy, Indore
  • Yashwardhan Saktawat College of Pharmacy, IPS Academy, Indore
  • Rajesh K Nema Rishiraj College of Pharmacy, Indore
  • Rajesh K Maheshwari Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore

Abstract

A novel, safe and sensitive method of spectrophotometric estimation in ultraviolet region has been developed using 7.5 M N, N- di methyl urea solution as hydrotropic agent for the quantitative determination of Naproxen, a poorly water-soluble drug in tablet dosage form. Naproxen shows maximum absorbance at 272 nm. Beer's law was obeyed in the concentration range of 10 to 60 μg/ml, N, N- di methyl urea does not absorb above 260 nm. Commonly used tablet excipients and N, N- di methyl urea did not interfere in spectrophotometric estimation. Results of the analysis were validated statistically and by recovery studies. Using 7.5 M N, N- di methyl urea solution for analysis of two different tablet formulations of Naproxen , the percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error. 

Keywords: Naproxen, hydrotropy, N, N- di methyl urea, spectrophotometry.
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How to Cite
Patel, M., Y. Saktawat, R. K. Nema, and R. K. Maheshwari. “New Spectrophotometric Method for the Estimation of Naproxen in Tablets Using N, N- Di Methyl Urea As Hydrotropic Agent”. Current Research in Pharmaceutical Sciences, Vol. 2, no. 3, Oct. 2012, pp. 177-9, http://crpsonline.com/index.php/crps/article/view/76.
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Research Articles