Synthesis, Characterization and Anti-inflammatory Activity of 1, 2, 4 Triazole Derivatives

  • Ruchi Bhatia Bansal College of Pharmacy Kokta, Anand Nagar, Bhopal-462021 Madhya Pradesh
  • Priyanka Rathore Bansal College of Pharmacy Kokta, Anand Nagar, Bhopal-462021 Madhya Pradesh
  • Satish Nayak Bansal College of Pharmacy Kokta, Anand Nagar, Bhopal-462021 Madhya Pradesh

Abstract

A series of 1, 2, 4 triazole derivatives were synthesized and evaluated for their anti-inflammatory activity by paw edema test. All the synthesized compounds were in good agreement with spectral and physical data. Most of the compounds synthesized were active and the most potent synthesized compounds showed greater % inhibition than the standard drug ibuprofen. Conclusions could be drawn from the synthesized compounds that sulfonyl group plays an important role in anti-inflammatory activity. The Cut off LD50 was found to be 500mg/kg for all synthesized compounds when given orally. 

Keywords: 1,2,4Triazole, Synthesis, Anti-inflammatory activity and LD50.
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How to Cite
Bhatia, R., P. Rathore, and S. Nayak. “Synthesis, Characterization and Anti-Inflammatory Activity of 1, 2, 4 Triazole Derivatives”. Current Research in Pharmaceutical Sciences, Vol. 2, no. 3, Oct. 2012, pp. 160-5, http://crpsonline.com/index.php/crps/article/view/73.
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Research Articles