Structure-Activity Relationships Among Novel 1,3,4-oxadiazole Analogues for Their Anti-inflammatory Activity

  • Harish Rajak Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) India
  • Vijay Patel Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) India
  • Deepak K Jain Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) India
  • Pramod K Dewangan Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) India
  • Prabodh C Sharma Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra136 119, (Haryana) India
  • Ravichandran Veerasamy Faculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, Malaysia
  • Arun K Gupta B.P.S. Mahila Vishwavidyalaya, Khapur-Kalan,Sonepat-131001, (Haryana) India
  • Jawahar S Dangi Medicinal Chemistry Research Laboratory, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur-495 009, (CG) India

Abstract

In pursuit of novel Non-Steroidal Anti-inflammatory Drugs (NSAID’s) and the significance of oxadiazoles as anti-inflammatory agent encouraged us to perform the synthesis of 1,3,4-oxadiazole analogues hitherto unreported for their anti-inflammatory activities. The structures of the compounds were confirmed by elemental analysis, IR, 13C-NMR and mass spectral data. The anti-inflammatory potential of the compounds were investigated using carrageenan-induced rat paw oedema method and cotton pellet-induced granuloma method. Some of the compounds displayed appreciable anti-inflammatory activity at doses of 100 mg/kg against Carrageenan-induced rat paw oedema assay, moist cotton pellet-induced and dry cotton pellet-induced granuloma method, respectively. Structure-activity relationships among synthesized compounds were established. 

Keywords: 1,3,4-oxadiazole, carrageenan-induced rat paw oedema method, cotton pellet-induced granuloma method.
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How to Cite
Rajak, H., V. Patel, D. K. Jain, P. K. Dewangan, P. C. Sharma, R. Veerasamy, A. K. Gupta, and J. S. Dangi. “Structure-Activity Relationships Among Novel 1,3,4-Oxadiazole Analogues for Their Anti-Inflammatory Activity”. Current Research in Pharmaceutical Sciences, Vol. 2, no. 3, Oct. 2012, pp. 142-8, http://crpsonline.com/index.php/crps/article/view/70.
Section
Research Articles

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