Stomach Specific Gastro retentive Drug Delivery System: A Review

  • H. K. Pathan Radharaman College of Pharmacy, Ratibad, Bhopal (M.P.), India
  • Amit Dasani Rajiv Gandhi institute of Pharmacy, Satana (M.P.), India
  • Ajay Saraf Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar (M.P.) India

Abstract

The aim of this review on Stomach specific gastro retentive drug delivery system attempts to compile the present information with all the possible approaches like mucobioadhesive system, swelling system, expanding system and floating system and other contributing factors used to achieve gastric retention and current technology and literature used in the development of gastro retentive dosage forms. To avoid the physiological troubles such as short gastric residence times and unpredictable gastric emptying times and inability to restrain and localize the system within the desired region of the gastrointestinal tract makes the need of development of stomach specific gastro retentive drug delivery system. This approach is currently utilized to facilitate local drug delivery to the stomach and significantly prolong the gastric residence time of drugs and improve bioavailability of drug after oral administration. Gastroretention could also help to administerd those drugs having narrow absorption window and shows the poor absorption in stomach therefore it could help to provide availability of new products and consequently improved therapeutic activity and substantial benefits to patients. 

Keywords: Gastric retention, Narrow absorption window, Gastro retentive approach, floating system.
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How to Cite
Pathan, H. K., A. Dasani, and A. Saraf. “Stomach Specific Gastro Retentive Drug Delivery System: A Review”. Current Research in Pharmaceutical Sciences, Vol. 2, no. 3, Oct. 2012, pp. 118-33, http://crpsonline.com/index.php/crps/article/view/68.
Section
Review Articles