Evaluation of Antidepressant Effect of 6-Shogaol in Animal Models

  • Payal Rahangdale Technocrats Institute of Technology – Pharmacy, Bhopal
  • Deepak Kumar Basediya Technocrats Institute of Technology – Pharmacy, Bhopal
  • Vivek Thakur Technocrats Institute of Technology – Pharmacy, Bhopal
  • Balkrishna Dubey Technocrats Institute of Technology – Pharmacy, Bhopal


The objective of the study was therefore to evaluate the role of 6-shogaol in the antidepressant effect Zingiber officinale using two different animal models viz., tail suspension test and forced swim test. Ginger rhizomes were extracted using water-methanol (80/20) as the solvent using maceration and 6-shogaol was isolated from the extract using mixture of n-hexane-diethyl ether (70/30, v/v) in column chromatography. The yield of the isolated 6-shogaol after column chromatographic isolation of the aqueous methanolic ginger extract was found to be 1.3%. The isolated 6-shogaol was of pale-yellow color and the texture appeared to be fine and crystalline. The forced swim test revealed that the immobility time was significantly reduced at all the administered doses of 6-shogaol in a dose dependent manner. The swimming time was found to increase in a similar fashion but was not significantly increased at a dose of 30 mg/kg of 6-shogaol. ANOVA analysis of the tail suspension test revealed that the reduction of immobility time was not significant at a dose of 30 mg/kg 6-shogoal whereas at doses of 100 and 300 mg/kg, the reduction was significant as compared to the control group.


Keywords: Shogaol, extract, tail suspension, forced swim, antidepressant, isolation


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How to Cite
Payal Rahangdale, Deepak Kumar Basediya, Vivek Thakur, and Balkrishna Dubey. “Evaluation of Antidepressant Effect of 6-Shogaol in Animal Models”. Current Research in Pharmaceutical Sciences, Vol. 12, no. 1, Apr. 2022, pp. 46-50, doi:10.24092/CRPS.2022.120107.
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