Review on Diabetic Nephropathy

  • Narendra Singh Kushmakar Department of Pharmacology and ToxicologyBR Nahata college of Pharmacy (A SIRO Recognized by DSIR ministry of Science and technology, GOI) Mhow – Neemuch Road Mandsaur (M.P) 458001
  • Abhilasha Jumnani R.N.S. Institute of Pharmacy Sitholi Gwalior (M. P.)


Diabetic nephropathy (DN) is one of the most frequent life threatening complications of diabetes
mellitus that occurs approximately 30-40%. It is usually attributed to metabolic consequences of
abnormal glucose regulations, such as elevated blood and tissue levels of glycosylated proteins and
hemodynamic changes within the kidney tissue. Recently there has been a renewed interest in
understanding the role of reactive oxygen species (ROS), which play a key intermediate role in the
pathophysiology of DN.

Keywords: diabetes mellitus, pathophysiology, Nephropathy, hyperglycaemia, anti oxidative mechanisms.


1. Sharma S, Kulkarni SK, Chopra K. Curcumin, The active principal of turmeric, ameliorates diabetic nephropathy in rates. Clin exp pharmacol 2006; 33: 940- 945.
2. Mclaughlin NG, Bhatt UY. Udayan. A review of the diagnosis and therapy of diabetic nephropathy.Northeast Florida Medicine Spring 2005; 27-32.
3. Vivian EM, Rubinstein GB. Pharmacologic management if Diabetic Nephropathy. Clinical Therapeutics. 2002; 24: 41-55.
4. Shumway TJ, Gambert RS. Diabetic nephropathy-pathophysiology and management. International Urology and Nephrology. 2002; 34:257-264.
5. Mclaughlin GN, Bhatt UY, Mars LR. A review of the diagnosis and therapy of Diabetic Nephropathy. Northeast Floroda Medicine 2005:27-31.
6. Fraser DJ, Phillips AO. Diabetic nephropathy. Medicine 2007; 35:503-506.
7. Watkins JP. ABC of Diabetes. 5th ed. BMJ Publishing Group Ltd, London 2003.
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How to Cite
Kushmakar, N. S., and A. Jumnani. “Review on Diabetic Nephropathy”. Current Research in Pharmaceutical Sciences, Vol. 1, no. 1, Dec. 2011, pp. 12-14,
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