Review on Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent life threatening complications of diabetes
mellitus that occurs approximately 30-40%. It is usually attributed to metabolic consequences of
abnormal glucose regulations, such as elevated blood and tissue levels of glycosylated proteins and
hemodynamic changes within the kidney tissue. Recently there has been a renewed interest in
understanding the role of reactive oxygen species (ROS), which play a key intermediate role in the
pathophysiology of DN.
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