Simultaneous Estimation of Lornoxicam and Paracetamol in Combined Tablet Dosage Form Using Reverse Phase High- Performance Liquid Chromatography Method

  • Prabha Shankar Maurya Faculty of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India
  • Mohd Javed Naim Faculty of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India
  • Neeraj Sharma Faculty of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India

Abstract

Using simple, precise, and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method, the synchronous of lornoxicam (LOR) and paracetamol (PCM) in the unite dosage form in the tablet has been established and confirmed. Acetonitrile: methanol: water is the mobile phase of the RP-HPLC method (pH adjusted with orthophosphoric acid), pH 3.8 (50:30:20 v/v/v), a diode array detector tuned to 290 nm was used to detect the signal. For LOR and PCM, chromatographic technique linearity was obtained in the concentration, ranges of 2-40 and 8–150 g/mL, respectively. In HPLC techniques, the recoveries were in the range of 99.85 0.0642 percent for LOR and 99.73 0.187 percent for PCM. Both approaches may be used to analyze the medicines in a pharmaceutical formulation regularly. The results of the analysis were statistically verified.1-2

Keywords: linearity, validation, oxicam, N-methyl Aspartate

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How to Cite
Prabha Shankar Maurya, Mohd Javed Naim, and Neeraj Sharma. “Simultaneous Estimation of Lornoxicam and Paracetamol in Combined Tablet Dosage Form Using Reverse Phase High- Performance Liquid Chromatography Method”. Current Research in Pharmaceutical Sciences, Vol. 11, no. 2, Sept. 2021, pp. 50-53, doi:10.24092/CRPS.2021.110202.
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Research Articles