Synthesis, Characterization and Antimicrobial Evaluation of some 1,2,4-Triazolo-5-Thione Derivatives

  • Gurdeep Singh School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab.
  • Neetesh K. Jain Oriental College of Pharmacy and Research, Oriental University, Indore (M.P.)
  • Kiran Sahu Oriental College of Pharmacy and Research, Oriental University, Indore (M.P.)


Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Therefore, an intense necessitate for new antimicrobial drugs. In current study, substituted 1,2,4-triazolo-5-thione derivatives were synthesized from substituted aromatic aldehydes, succinic acids and the structure of synthesized compounds were established by physicochemical (Melting Point, Rf value) and spectral analysis (IR, NMR & Mass). The title compounds were then evaluated for their antimicrobial activity against ciprofloxacin as a standard drug using agar plate method. Among all synthesized derivatives A5 and A6 found were found to possess very promising antimicrobial activity. 

Keywords: 1,2,4-triazolo-5-thione, anti-microbial, antibiotic, thione, Ciprofloxacin


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How to Cite
Gurdeep Singh, Neetesh K. Jain, and Kiran Sahu. “Synthesis, Characterization and Antimicrobial Evaluation of Some 1,2,4-Triazolo-5-Thione Derivatives”. Current Research in Pharmaceutical Sciences, Vol. 11, no. 1, May 2021, pp. 24-30, doi:10.24092/CRPS.2021.110103.
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