Nanosponges: A Promising Nanocarrier Systems for Drug Delivery

  • Mukesh Kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, N. H.58, Delhi-Roorkee Highway, Baghpat Bypass Road Crossing, Meerut, Utter Pradesh 250005, India
  • Priya Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET), NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India
  • Anoop Kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET), NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India
  • Shobhit Kumar Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET), NH-58, Delhi-Roorkee Highway, Meerut-250005, Uttar Pradesh, India


Nanoengineered drug delivery system is generally used to solubilize the hydrophobic drugs. They also carry the drug to the target site and release the drug according to need of patient. These are very effective drug carriers which minimize and resolve the problems of drug toxicity and poor bioavailability as they can load both hydrophilic and hydrophobic drugs. Nanosponges are tiny in size with three dimensional networks. These are highly porous in nature and entrap active moieties and provide an advantage of programmable release. These are prepared by cross linking using many type of cyclodextrin with carbonyl and dicarboxylate compound like cross linker. Nanosponges are used for enhancing the bioavailability of drug and delivery of drug via oral, topical and parenteral routes. These are also used as a carrier for release of enzyme, protein, vaccines and antibiotics.

Keywords: Nanocarrier, Nanosponges, Targeted drug delivery


1. Naga SJ, Nissankararao S, Bhimavarapu R, Sravanthi S, Vinusha K. Nanosponges: a versatile drug delivery system. Int J Pharm Life Sci, 2013;4:2920-5.
2. SS, SA, Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery system. J Pharm Pharm 2012; 15:103-11.
3. Tejashri G, Amrita B, Darshana J. Cyclodextrin based nanosponges for pharmaceutical use: a review. Acta Pharm. 2013; 63:335-58.
4. Che-Ming J. Hu, Ronnie H. Fang, Jonathan Copp, Brian T. Luk, and Liangfang Zhang. A biomimetic nanosponge that absorbs pore-forming toxins. PMC, 2013; 8: 336–340.
5. Swaminathan S, Cavalli R, Trotta F. Cyclodextrin-based nanosponges: a versatile platform for cancer nanotherapeutics development. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016; 8:579-601.
6. Minelli R, Cavalli R, Ellis L, Pettazzoni P, Trotta F, Ciamporcero E, Barrera G Fantozzi RDianzani CPili RWiley Interdiscip Rev Nanomed Nanobiotechnol. Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells.European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences. 2012, 47:686-694.
7. Trotta F,/ Znetti M, Cavalli R. Cyclodextrin-based nanosponges as drug carriers.Beilstein J Org Chem. 2012; 8:2091–2099.
8. Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation. Int J Nanomedicine. 2015; 10:893–902.
9. Stevens DM, Tempelaar S, Dove AP, Harth E. Nanosponge formation from organocatalytically-synthesized poly(carbonate) copoplymers. PMC 2014; 1:915–918.
10. Byeon JH. Photo-derived transformation from modified chitosan@calcium carbonate nanohybrids to nanosponges. Sci Rep. PMC 2016; 6:28782.
11. Sherje AP, Dravyakar BR, Kadam D, Jadhav M. Cyclodextrin-based nanosponges: A critical review. Carbohydr Polym. 2017; 173:37-49.
12. Zhu C, Guo S, Dong S. Rapid, General synthesis of PdPt bimetallic alloy nanosponges and their enhanced catalytic performance for ethanol/methanol electrooxidation in an alkaline medium. Chem a Eur J. 2012; 201202909
13. Moin A, Deb TK, Osmani RAM, Bhosale RR, Hani U. Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy. J Basic Clin Pharm. 2016; 7:39–48.
14. Shirsand SB, Para MS, Nagendrakumar D, Kanani KM, Keerthy D. Formulation and evaluation of Ketoconazole niosomal gel drug delivery system. Int J Pharm Investig. 2012; 2:201–207.
15. Bhatt PC, Srivastava P, Pandey P, Khan W, Panda BP. Nose to brain delivery of astaxanthin loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies. Royal Society of Chemistry. 2016:6:10001.
16. Pandey YR, Kumar S, Gupta BK, Ali J, Baboota S. Intranasal delivery of paroxetine nanoemulsion via the olfactory region for the management of depression: formulation, behavioural and biochemical estimation. IOP Publishing 2015; 27:025102.
17. Rahi N, Kumar K. Nanosponge: A new era of versatile drug delivery system. UJPR 2017; 2:31-39.
18. Xiao M, Feng L, Zhu J, Liu C, Xing W. Rapid synthesis of a PtRu nano-sponge with different surface compositions and performance evaluation for methanol electrooxidation. Royal society of chemistry 2015:1-5.
19. Zhu C, Wen D, Leubner S, Oschatz M, Liu W, Holzschuh M, Simon F, Kaskel S, Eychmüller A. Nickel cobalt oxide hollow nanosponges as advanced electrocatalysts for the oxygen evolution reaction. Royal society of chemistry. 2015:7:1-4.
20. Aggarwal G, Nagpal M, Kaur G. Development and Comparison of nanosponge and niosome based gel for the topical delivery of tazarotene. Pharm Nanotechnol. 2016; 4:213-228.
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How to Cite
Mukesh Kumar, Priya, Anoop Kumar, and Shobhit Kumar. “Nanosponges: A Promising Nanocarrier Systems for Drug Delivery”. Current Research in Pharmaceutical Sciences, Vol. 10, no. 1, May 2020, pp. 01-05, doi:10.24092/CRPS.2020.100101.
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