Hepatoprotective Activity of Ficus religiosa Leaf Extract in Rats

  • Archna Selvan RKDF College of Nursing, Bhopal (MP), India
  • Vivek Chourasia RKDF College of Pharmacy, Bhopal (MP), India


Ficus religiosa was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage. IV administration of a sub-lethal dose of paracetamol (500 mg/kg) produced liver damage in rats as manifested by the rise in serum level of transaminases (AST and ALT). Ttreatment of rats with Ficus religiosa(200 mg/kg) prevented the paracetamol-induced rise in serum enzymes. The hepatotoxic dose of CCl4 (1.5 ml/kg; orally) also raised the serum AST and ALT levels. The same dose of Ficus religiosa(200 mg/kg) was able to prevent the CCl4-induced rise in serum enzymes. These results indicate that Ficus religiosa possesses hepatoprotective activity. 

Keywords: Ficus religiosa, paracetamol, CCl4, Hepatoprotective.


1. Valiathan MS. Healing plants. Curr Sci 1998; 75: 1122-1127.
2. Kirthikar KR, Basu BD. Indian medicinal plants. Vol. 3, 2nd ed, India: International Book Distributors, 1996. p. 2329-2331.
3. Nadkarni KM, Nadkarni AK. Indian material medica. Vol. 1, India: Popular Prakashan, 1995. p. 545- 547.
4. Seong-Kuk K, Dong-Ok C, Hee-Jong C. Purification and identification of antimicrobial substances in phenolic fraction of fig leaves. Han'guk Nonghwa Hakhoechi 1995; 38: 293-296.
5. Jeong WS, Lachance PA. Phytosterols and fatty acids in fig (Ficus carica, var. Mission) fruit and tree components. J Food Sci 2001; 66: 278-281.
6. Weiping Y, Hongming C, Tianxin W, Mengshen C. A new coumarin compound with anticancer activity. Zhongcaoyao 1997; 28: 3-4.
7. Shai R, Yoel K, Ruth R, Michael S, Raphael M. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation. J Nat Prod 2001; 64: 993-996.
8. Saeed MA, Sabir AW. Irritant potential of triterpenoids from Ficus carica leaves. Fitoterapia 2002; 73: 417-420.
9. Subhash CM, Tapan KM, Das J, Pal M, Saha BP. Hepatoprotective activity of Ficus racemosa leaf extract on liver damage caused by carbon tetrachloride in rats. Phytother Res 1999; 13: 430-432.
10. Subhash CM, Saraswathi B, Ashok Kumar CK, Mohana Lakshmi S, Maiti BC. Protective effect of leaf extract of Ficus hispida Linn against paracetamol-induced hepatotoxicity in rats. Phytother Res 2000; 14: 457-459.
11. Bhattacharjee SK Handbook of Medicinal Plants. Pointer Publishers, Jaipur, India.
12. Brown VK, Robinson V & Stevenson DE (1963) A note on the toxicity and solvent editions, properties of dimethylsulphoxide. Journal of Pharmaceutical Pharmacology 15: 688-692
13. Chopra RN, Chopra IC, Handa KL & Kapin LD. Indigenous Drugs of India. U.N. Dhur and Sons Private Ltd., Calcutta, India.
286 Views | 213 Downloads
How to Cite
Selvan, A., and V. Chourasia. “Hepatoprotective Activity of Ficus Religiosa Leaf Extract in Rats”. Current Research in Pharmaceutical Sciences, Vol. 7, no. 2, July 2017, pp. 64-68, doi:10.24092/CRPS.2017.070205.
Research Articles