Evaluation of Pharmacological Potential of Tamarindus indica in Streptozotocin Induced Diabetic Rats

  • Bibekananda Meher Faculty of Pharmacy IFTM University, Moradabad Uttar Pradesh-244102, India

Abstract

Diabetes mellitus is associated with dyslipidemia. The present study was carried out to evaluate the antidiabetic and hypolipidemic potential of hydro-alcoholic and aqueous seeds extract of Tamarindus indica on Streptozotocin induced diabetic rats. In oral glucose tolerance test the blood glucose level was significantly (P<0.05) controlled in 0-90 min after glucose administration in normal and streptozotocin induced diabetic rats. The blood glucose level of Streptozotocin induced diabetic rats were determined at 0,7,14 days of treatment after 14 days of treatment blood glucose levels were significantly (P<0.05) decreased. Hydro-alcoholic seeds extract at the dose of 200 mg/kg significantly increased the serum insulin level. Tamarindus indica seeds extracts at all the dose level 100 and 200 mg/kg, after 14 day days of treatment significantly (P<0.05) increased hepatic glycogen level. On the other hand after 14 days of treatment lipid profile cholesterol (CHOL), high density lipoprotein (HDL), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) were significantly (P < 0.05) improved in diabetic rats treated with Tamarindus indica seeds extracts. The results suggested that the both hydro-alcoholic and aqueous extracts of Tamarindus indica seeds possess potential antidiabetic, hypolipidemic effect.

Keywords: Diabetes mellitus, hypolipidemic, Tamarindus indica, insulin, streptozotocin.

References

1. Meher B, Dash DK, Roy A. A review on: Phytochemistry, Pharmacology and Traditional uses of Tamarindus indica L.WJPPS.2014; 3(10):229-24.
2. Kumar M, Rani M, Meher B. Review on Pharmacology and Phytochemistry of Cyperus rotundus L. Curr. Res. Pharm. Sci. 2017; 07 (01): 11-15.
3. Shokeen P, Anand P, Murali YK, Tandon V. Food Chemical Toxicology. 2008; 46(11): 3458-3466.
4. Strohl WR. The Role of Natural products in a Modern Drug Discovery Program. Drug Discovery Today. 2000; 5:39–41.
5. Alikhan I, Khanum A. Herbal Medicine for Human Diseases. 1st ed. Ukaaz Publications, Hyderabad (2007).
6. WHO, WHO/NMH/CHP/CPM/11.1, Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus; 2011.
7. Garry JD, Banting CML. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 2002; 51: 7–18.
8. Meher B, Dash DK, Roy A. A review on: Phytochemistry, Pharmacology and Traditional uses of Tamarindus indica L. WJPPS. 2014; 3(10):229-240.
9. Komutarin T, Azadi S, Butterworth L, Keil D, Chitsomboon B, Suttajit M et al.,. Extract of the seed coat of Tamarindus indica inhibits nitric oxide production by murine macrophages in vitro and in vivo. Food and Chemical Toxicology. 2004;42: 649–658.
10. Basu K, Singh B, Singh MP. Indian Medicinal Plants, 4th ed, 2006, pp. 887-890.
11. Iyer SR, Tamarindus indica Linn. In: Warrier, PK, Nambiar VPK, Kutty CR (Eds.). Indian Medicinal Plants, vol. V. Orient Longman Limited, Madras, pp. 235–236, 1995.
12. Chopra RN, Nair SL and Chopra JC. Glossary of Indian medicinal Plants. CSIR Publication, New Delhi (1992).
13. OECD Guideline For The Testing of Chemicals: Acute oral toxicity-Acute Toxic Class Method (2001) 423.
14. Shankar PK, Kumar V, Rao N. Evaluation of antidiabetic activity of Ginkgo biloba in Streptozotocin induced diabetic rats, Iranian Journal of Pharmacology and Therapeutics. 2005; 4: 16-19.
15. Minzhu C. Experimental methods of corticoids and its antagonists. In: Shuyun X, Rulian, B. (Eds.), Methodology of Pharmacological Experiments. The People’s Medical Publishing House, Beijing:(1994)1246–1260.
16. George LE. Tissue Sulfhydryl Groups. ABB. 1959; 82(1): 70-77.
17. Maiti R, Jana D, Das UK and Ghosh D. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology. 2004; 92: 85–91.
18. Onga KW. Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin induced diabetic rats. Journal of Ethnopharmacology. 2011; 133:598–607.
19. Al-Shamaony L, Al-Khazraji SM, Twaiji HA. Antidiabetic effect of Artemisia herbaalba II. Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology. 1994; 43:67–171.
20. Zhang L, Yang J, Chen X, Zan K, Wen X, Chen H, Wang Q, Lai MX. Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin. Journal of Ethnopharmacology. 2010; 132: 518–524.
21. Grover JK, Vats V, Yadav S. Effect of feeding aqueous extract of Petrocarpus marsupiun on glycogen content of tissues and the key enzymes of carbohydrate metabolism. Molecular Cellular Biochemistry. 2002; 241: 53–59.
22. Sharma SB, A Nasir A, Prabhu K, Murthy PS, Dev G. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits, Journal of Ethnopharmacology. 2003; 85: 201–206.
23. Pushparaj PN, Low HK, Manikandan J, Tan BKH, Tan CH. Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats, Journal of Ethnopharmacology. 2007; 111: 430–434.
24. Sakatani T, Shirayama T, Suzaki Y, Yamamoto T, Mani H, Kawasaki T, Sugihara H, Matsubara H. The association between cholesterol and mortality in heart failure. Comparison between patients with and without coronary artery disease, International Heart Journal. 2005; 46:619–629.
25. Alberti KGMM, Zimmet P, Fronozo RAD. International Textbook of Diabetes mellitus. 2nd ed. John Wiley and Sons, New York (1997).
26. Ananthan R, Latha M, Ramkumar KM, Pari L, Baskar C, and Bai VN. Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats. Experimental Diabetes Research. 2003; 4:183-189.
Statistics
34 Views | 36 Downloads
How to Cite
Meher, B. “Evaluation of Pharmacological Potential of Tamarindus Indica in Streptozotocin Induced Diabetic Rats”. Current Research in Pharmaceutical Sciences, Vol. 7, no. 2, July 2017, pp. 50-57, doi:10.24092/CRPS.2017.070203.
Section
Research Articles