Development and in vitro Evaluation of Floating Microparticles of Cimetidine

  • Nidhi Jain Department of Pharmacy, Barkatullah University, Bhopal, Madhya Pradesh462026, India
  • Rahul Gupta Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India

Abstract

Microspheres of Cimetidine by emulsion solvent diffusion technique were prepared for sustained delivery by using polymers like Ethyl cellulose and Carbopol 934in order to extend the drug release for about 12 h in the upper GIT, which may result in enhanced absorption and there by improved bioavailability. The particle size was determined by optical micrometer and average particle size was found to be in range of89.5± 2.63 to 124.33± 2.14. Formulation F2 containing Ethyl cellulose and Carbopol 934 polymer blend showed the best floating ability (97.5%) as compared with other formulations. From Scanning Electron Microscopy (SEM) it was observed that, Microparticles were found to be spherical in shape with smooth surface texture with a hollow space within. Among all formulations, F2 showed appropriate balance between buoyancy and drug release rate of 88.65% in 12 h, which was considered as the best formulation. 

Keywords: Cimetidine, Microparticles, Emulsion solvent diffusion technique, Buoyancy, Bioavailability.

References

1.Begum ASK, Basava RD. Formulation development and evaluation of Cimetidine floating microspheres. IJPRIF. 2016; 9: 182-192.
2.Kumari K, Sharma P, Gupta R. Polysorbate-Phospholipid Complex Micelles as P-glycoprotein Inhibitor Drug Delivery System. JBPT. 2017; 1: 2-7.
3.Trivedi P, Verma AML, Garud N. Preparation and characterization of aceclofenac microspheres. Asian J Pharm. 2008; 19: 110-115.
4.Mathur P, Seth PR. Floating drug delivery system, An innovative acceptable approach in gastroretentive drug delivery and novel dosage forms which retained in the stomach for prolong and predictable period of time. Arch App Sci Res. 2010; 2:257-270.
5.Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int. J. Pharm. 2003; 241: 279-292.
6.Rajput G, Majmudar F, Patel J, Thakor R, Rajgor NB. Stomach-specific mucoadhesive microsphere as a controlled drug delivery system. Sys Rev Pharm. 2010; 1: 36-44.
7.Kawashima Y, Niwa T, Takeuchi H , Hino T , Itloh Y . Hollow microspheres for use as floating drug delivery System in the stomach. J Pharm ScI. 1992; 8:135-140.
8.Dubey RR. Two stage optimization process for formulation of Chitosan Microspheres. AAPS Pharm Sci Tec. 2004; 1:451-454.
Statistics
4 Views | 6 Downloads
How to Cite
Jain, N., and R. Gupta. “Development and in Vitro Evaluation of Floating Microparticles of Cimetidine”. Current Research in Pharmaceutical Sciences, Vol. 7, no. 1, May 2017, pp. 25-29, doi:10.24092/CRPS.2017.070104.
Section
Research Articles