Formulation and Evaluation of Fast Dissolving Tablet of Glimepiride
Glimepiride is a first third generation sulphonyl urea agent for the treatment type II diabetes mellitus. The main objective of present work was to formulate and evaluate fast dissolving tablet of glimepiride by using different concentration of super disintegrating agents. Glimepiride is given once daily in doses from 1-8 mg. The fast dissolving tablets of glimepiride was prepared from F1- F4 by direct compression method.The drug and excipients were evaluated for angle of repose, bulk density, tapped density, Carr’s index and hausner’s ratio for the determination of flow property of powder. The formulated tablets were evaluated for thickness, hardness, friability, wetting time, water absorption and dispersion time. The obtained results were clearly indicating that the formulated tablets results are within the range and when compared with all formulations, F4 was the best formulation among the four formulations.
2.Lieberman A. Herbert, Lachman Lion, Schwartz B. Joseph. Pharmaceutica dosage forms: Tablets, CBS Publisher and Distributers New Delhi. 2005; 3: 200-214.
3.Ito A. and Sugihara M. Development of oral dosage form for elderly patients: use of agar as base of rapidly disintegrating oral tablets. Chem Pham Bull 2011; 11: 2132-2136.
4.Sunada H and Bi Y, Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technology2012; 122: 188–198.
5.Jayesh P, Manish R. Tablet Formulation design and manufacture: Oral immediate release application. Pharma times 2009; 4: 21-29 .
6.Narmada GY. Formulation, Evaluation and Optimization of Fast Dissolving Tablets Containing Amlodipine Besylateby Sublimation Method, ARS Pharmaceutica 1950; 3: 129-144.
7.Deepak S, Mankaran S, Dinesh K & Gurmeet S. Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for Paediatrics and Geriatrics Journal of Pharmaceutics 2014; 8-16.
8.Biradar SS. Fast dissolving drug delivery systems: a brief overview. The Int. J. Pharmacol, 2014; 2: 1531-2976.
9.Shu T. Studies of rapidly disintegrating tablets in oral cavity using coground mixture of mannitol with crospovidone, Chem Pharm Bull 2002; 50:193-8.
10.Kuccherkar B. Mouth dissolving tablets: A novel drug delivery system. Pharma. Times 2013; 35: 3-10.
11.Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste masking and clinical studies. Critical reviews in therapeutic drug carrier system2004; 21: 433-76.
12.Mizumoto T, Masuda Y et al. Formulation design of a novel fast disintegrating tablet. International Journal of Pharmaceutics 2005; 306: 83-90.
13.Mizumoto T, Masuda Y et al. Formulation design of a novel fast disintegrating tablet. Internationl Journal of Pharmaceutics 2005; 306(1-2): 83-90.