Recent Trends in Therapeutic Radiopharmaceuticals

  • Chandan B Jha Department of Pharmacy, Barkatullah University, Bhopal, M.P, India
  • Nidhi Jain Department of Pharmacy, Barkatullah University, Bhopal, M.P, India
  • A K Pathak Department of Pharmacy, Barkatullah University, Bhopal, M.P, India


Radiopharmaceuticals have been majorly used in ages for the diagnostic agent and therapeutic agents .Recent years enormous efforts have been made to formulate holistic formulation for the therapeutic effect of Radiopharmaceuticals .Due to its versatile applications in cancer , Theraspheres -which are glass beads microparticals containing yttrium 90 isotope as a therapeutic agents for Osteosarcoma and its liposomes containing yttrium 90 for the treatment of throat and neck cancer have been formulated .These new formulations have added a new dimension in the field of Research and Development .This review explains need of Radiopharmaceuticals ,their advantages over conventional drug delivery systems and there different application in pharmaceutical fields. 

Keywords: Radiopharmaceuticals, Osteosarcoma, Therasphere, Yttrium 90, Hydroxyapatite


1. Harbert JC. Therapy with intra-arterial radioactive particles. In Harbert JC, EckelmanWC, and Neumann RD(Eds). Nuclear medicine: Diagnosis and therapy. Thieme Medical Publishers, New York, 1996, Page No.-1141-1155
2. Blanchard RJ, Grotenhuis I, LaFave JW, Frye CW, and Perry JN. Treatment of experimental tumours. Arch Surg. 1964; 89: 406-410.
3. Knight CG, Bard DR and Page Thomas DP. Liposomes as carriers of antiarthritic agents. Ann. N.Y. Acad. Sci. 1988; 415-428.
4. Hafeli U, German R, Pauger G, Casillas S, and Dietz D. Production of Rhenium – powder with a jet mill and its incorporation in radioactive microsphere for treatment of liver tumours. In Bryskin BD(Ed). Rhenium and Rhenium Alloys. TMS(Minerals, Metals and Material Society), Warrendale, PA. (1997) Pp 469-477
5. Zalutsky MR, Noska MA, Gallagher PW, Shortkroff S, AND Sledge CB. Use of liposomes as carriers for radiation synovectomy. Nucl. Med. Biol. Int. J. Rad. Appl. Instr. Part B. 1988; 151-156.
6. Papisov MI, Savelyev VY, Sergienko VB, and Torchilin VP. Magnetic drug targeting. In vivo Kinetics of radiolabeled magnetic drug carriers. Int. J. Pharm. 1987; 201-206.
7. Zielinski FW, Kasprzyk. Synthesis and quality control testing of P-32 Labeled ion exchange resin microsphere for radiation therapy of hepatic neoplasms. Int. J. Radiat Isot. 1983; 1343-1350.
8. Robertson WW, Janssen HF, Walker RN. Passive movement of radioactive microsphere from bone and soft tissue in extremity. J. Orthop Res. 1985;405-411.
9. Grady ED. International radiation therapy of hepatic Cancer. Dis Colon Rectum. 1979; 371-376.
10. Wunderlich G, Pinkert J, Andreeff M, Stintz M, Knapp FF Jr, Kropp J, Franke WG. Preparation and biodistribution of rhenium-188 labeled albumin microsphere B20: a promising new agent for radiotherapy. Appl Radiat Isot. 2000; 63-68.
11. Yan, Morris. Hepatic cryotherapy for liver metastases from colorectal carcinoma. ANZ journal of Surgery. SRS 39th Annual Scientific Meeting, (2002).
12. V.R Sinha, V. Goyel, A. Trehan. Radioactive Microsphere in therapeutics. Pharmazie 2004; 59: 419-426.
13. Urs Hafeli. Radioactive Microsphere for Medical Application. Cleveland Clinic Foundatio, Radiation Oncology Department T28. Page No.-3-29.
14. Marcelo F, Cipreste, Edesia M.B. Sousa. Polyvinyi alcohol/collagen/hydroxyapatite Nanoparticles Hybrid SystemContaining Yttrium-90 as a potential Agent to treat Osteosarcoma. Journal of Biomaterials and Nanobiotechonology. 2014; 24-30.
15. Delbarre F, Roucayrol JC, Ingrand J, Sanchez A, Menkes CJ, and Aignan M, Une nouvelle. Yttrium-90 in persistent synovitis of knee- a single centre comparision. The retention and extra- articular spread of four yttrium-90 radiocolloids. Brit. J. Radiology. 1975; 377-381.
16. Remington, “The Science and Practice of Pharmacy, 21st Edition, Published By Lippnicott Williams & Wilkins, Volume-I, Page No.- 479-492.
17. The United State Pharmacopeia & The National Formulary-2000, Asian Edition. Published By United states Pharmacopeial Convention, INC. Page No.-1988-1990.
18. Bentley’s, “ Textbook of Pharmaceutics”, 8th Edition. Published By Bailliere Tindall London, Page No.-367-429.
19. Ansel’s, “Pharmaceutical Dosage Forms and Drug Delivery Systems”, 8th Edition, Publishe By Lippnicott Williams & Wilkins, Page No.-570-599.
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How to Cite
Jha, C. B., N. Jain, and A. K. Pathak. “Recent Trends in Therapeutic Radiopharmaceuticals”. Current Research in Pharmaceutical Sciences, Vol. 6, no. 2, July 2016, pp. 27-30,
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