A simple UV Spectrophotometric method for Quantitative Estimation of Enalapril maleate

  • Neelkant Prasad Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P., India- 201201
  • Rajeev Kumar Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P., India- 201201
  • Vipin Kumar Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P., India- 201201
  • Ram Kumar Roy Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, U. P., India- 201201

Abstract

A simple UV spectrophotometric method is described here to analyze enalapril maleate in bulk and dosage forms. The method is based on oxidation of enalapril maleate with potassium permanganate and sulphuric acid. The reaction is followed by measuring the absorbance at 267 nm. Beer’s law is obeyed in the concentration ranges of 250-500 μg ml-1, respectively. The method has been applied to the determination of enalapril maleate in bulk. Results of analysis are validated statistically and as per ICH guidelines. The method is found to be specific, repeatable, accurate and precise. 

Keywords: Enalapril maleate, spectrophotometry, ICH guidelines, oxidation, potassium permanganate

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How to Cite
Prasad, N., R. Kumar, V. Kumar, and R. K. Roy. “A Simple UV Spectrophotometric Method for Quantitative Estimation of Enalapril Maleate”. Current Research in Pharmaceutical Sciences, Vol. 6, no. 1, Apr. 2016, pp. 21-26, http://crpsonline.com/index.php/crps/article/view/156.
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Research Articles