Anti-fertility Effect of Stem bark of Ailanthus excelsa in Wistar Albino Rats

  • Munesh Mani Institute of Pharmacy, NIMS University, Jaipur-303121
  • Devendra S Rathore Institute of Pharmacy, NIMS University, Jaipur-303121


Ailanthus excelsa (Family: Simaroubaceae) is commonly known as Mahanimba and Arlu. In this study stem bark of Ailanthus excelsa were evaluated by anti-implantation and abortifacient method at three doses i.e. 100mg/Kg, 150mg/Kg and 200mg/Kg of the body weight of the rat. It was observed that treatment with methanolic extract of Ailanthus excelsa at the dose of 200 mg/kg was shown significant anti-fertility effect. Ailanthus excelsa possess anti-fertility activity by inhibiting implantation and abortifacient action. 

Keywords: Antifertility, abortifacient, Ailanthus excelsa, implantation


1.Mani M, Sachan N, Chandra P, Mahur K. et al. Antidiarrhoeal Potential of methanolic extract of root bark of Ailanthus excelsa Journal of Pharmacy Research. 2011;4(2):422-423
2.Ghosh K, Bhattacharya TK. Preliminary study on the anti-implantation activity of compounds from the extracts of seeds of the Spesia populnea. Indian Journal of Pharmacology 2004; 36(5): 288–291.
3.Aitken RJ, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJK. As the world grows: contraception in the 21st century. Journal of Clinical Investigation 2008; 118(4): 1330–1343.
4.Chauhan A, Agarwal M, Kushwaha S, and Mutreja A. Antifertility studies of Aegle marmelos Corr., an Indian medicinal plant on male albino rats. Egyptian Journal of Biology 2008;10: 28–35.
5.Negi AS, Dwivedi I, Setty BS, and Ray S. Benzophenones, naphthophenones and related compounds as spermicidal agents. Indian Journal of Pharmaceutical Sciences. 1994; 56(3): 105–108.
6.Bagul MS, Kanaki NS and Rajani M. Evaluation of free radical scavenging properties of two classical polyherbal formulations. Indian Journal of Experimental Biology 2005; 43(8): 732–736.
7.Bhandari DS, Gupta ML. Studies on the digestibility and nutritive value of Arlu Ailanthus excelsa. The Indian veterinary Journal. 1972; 49(5): 512-516
8.Agrawal SS and Paridhavi M, Herbal drug technology, Universities Press, Hyderabad (2007) 490-491.
9.Kokate CK. Practical Pharmacognosy. (2010); 4th edt. Nirali Publication, 136-154
10.OECD Guideline for the testing of chemicals: Acute oral toxicity-acute toxic class method. 2001, 423.
11.Pare S, Varsha Zade V, Dabhadkar D. Evaluation of potential antifertility activity of plant Trianthema portulacastrum in female albino rat. Int. J.A.PS. 2013; 2(1): 7‐11.
12.Khanna U, Chaudhury RR, Antifertility screening of plants. Part I. Investigation of Butea monosperma (Lam) Kutze. Ind. J. Med. Res. 1968; 56: 1575–1579.
13.Ajayi AF, Akhigbe RE. Antifertility activity of Cryptolepsis sanguinolenta leaf ethanolic extract in male rats. Journal of human Reproductive sciences. 2012; 5(1):43-47.
14.Yang JG, Dang YG, Li GY, Guo LJ, Wang WT, Tan QW, Lin QY, Wu ZJ, Xie LH. Antiviral activity of Alianthus altissima crude extract on rice stripe virus in rice suspension cells. Phytoparasitica. 2008; 36(4): 405-408.
15.Ravichandran V, Suresh B, Sathishkumar MN, Elango K, Srinivasan R. Antifertility activity of hydroalcoholic extract of Ailanthus excelsa (Roxb): an ethnomedicines used by tribals of Nilgiris region in Tamilnadu. J Ethnopharmacol. 2007; 112(1):189-91.
16.Dhanasekaran S, Suresh B, Sethuraman M, Rajan S, Dubey R. Antifertility activity of Ailanthus excelsa Linn. in female albino rats. Indian J Exp Biol. 1993; 31(4): 384-5.
17.Tamboli SA, konadawar MS. Anti-implantation activity of the leaf extracts of Ailanthus excelsa roxb International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5 (4): 128-129.
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How to Cite
Mani, M., and D. S. Rathore. “Anti-Fertility Effect of Stem Bark of Ailanthus Excelsa in Wistar Albino Rats”. Current Research in Pharmaceutical Sciences, Vol. 6, no. 1, Apr. 2016, pp. 16-20,
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