Design and Characterization of Floating Tablet of Rabeprazole

  • Manoj Kumar Goyal Department of Pharmaceutics, College of Pharmacy, Institute of Professional Studies, Shivpuri Link Raod, Gwalior-474001, Madhya Pradesh, India
  • Ashutosh Dubey Department of Pharmaceutics, College of Pharmacy, Institute of Professional Studies, Shivpuri Link Raod, Gwalior-474001, Madhya Pradesh, India
  • Hariom Tyagi Department of Pharmaceutics, College of Pharmacy, Institute of Professional Studies, Shivpuri Link Raod, Gwalior-474001, Madhya Pradesh, India

Abstract

The present study was aimed at preparing sustained floating drug delivery system of Rabeprazole to increase its gastric residence time and bioavailability after oral administration. Total ten formulations were formulated by direct compression technique using HPMC K15M, HPMC K100M and ethyl cellulose (floating agent) as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluated for their physicochemical properties, buoyancy lag time, total floating time, swelling index and invitro drug release. All ten formulations possessed good floating properties with total floating time >12 hrs. 

Keywords: gastroretentive drug delivery, ethyl cellulose, HPMC, effervescent, sustained release
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How to Cite
Goyal, M. K., A. Dubey, and H. Tyagi. “Design and Characterization of Floating Tablet of Rabeprazole”. Current Research in Pharmaceutical Sciences, Vol. 5, no. 3, Oct. 2015, pp. 106-11, http://crpsonline.com/index.php/crps/article/view/146.
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Research Articles