Preparation and Evaluation of Bi-layer Floating Tablet of ydrochlorothiazide and Propranolol HCl

  • Pushkal Gupta Department of Pharmacy, Barkatullah University, Bhopal. 462026.
  • Ashwani Mishra Department of Pharmacy, Barkatullah University, Bhopal. 462026.
  • Anupam Pathak Department of Pharmacy, Barkatullah University, Bhopal. 462026.

Abstract

Bi-layer tablets consist of two layers which contain one or more drug. Sometimes it can be used to get modified release profile of the formulation by formulating individual layers using different sort of polymer. In this work attempt was made to formulate a tablet having one floating layer of Propranolol HCl and immediate release layer of Hydrochlorothiazide. Different concentration of carbopol, microcrystalline cellulose, sodium bicarbonate, citric acid sodium starch glycolate and Hydroxy propyl methyl cellulose were used to formulate bi layer tablets. Prepared formulations were evaluated for weight variation, friability, hardness, floating time and in vitro drug release .The best formulation F6 which passes all the evaluations was consider as the promising formulation of hydrochlorothiazide and Propranolol HCl. 

Keywords: Quinazolinone, Schiff base, chalcone, anti-inflammatory activity.
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How to Cite
Gupta, P., A. Mishra, and A. Pathak. “Preparation and Evaluation of Bi-Layer Floating Tablet of Ydrochlorothiazide and Propranolol HCl”. Current Research in Pharmaceutical Sciences, Vol. 5, no. 2, June 2015, pp. 51-57, http://crpsonline.com/index.php/crps/article/view/141.
Section
Research Articles