Utilization of Lawsonia Inermis Mucilage as a Novel Binder in Conventional Tablet Dosage Form

  • Yogesh Joshi Himalayan Institute of Pharmacy and Research, Atakfarm, Rajawala, Dehradun-248007, Uttarakhand, India
  • Punit Bisht Himalayan Institute of Pharmacy and Research, Atakfarm, Rajawala, Dehradun-248007, Uttarakhand, India
  • Aarti Bhatt Himalayan Institute of Pharmacy and Research, Atakfarm, Rajawala, Dehradun-248007, Uttarakhand, India
  • Divya Juyal Himalayan Institute of Pharmacy and Research, Atakfarm, Rajawala, Dehradun-248007, Uttarakhand, India
  • Satyanandam Sade Himalayan Institute of Pharmacy and Research, Atakfarm, Rajawala, Dehradun-248007, Uttarakhand, India

Abstract

The study was involved to formulate oral tablet dosage form of diclofenac sodium using mucilage extracted from the Lawsonia inermis as a binder. Purified extracted mucilage was subjected to physicochemical characterization and four formulations each containing 100mg of Diclofenac sodium were prepared by wet granulation method using different mucilage concentrations viz. 2.5, 5, 7.5 and 10 % w/w. Lactose was used as diluent while magnesium stearate and talc were employed as lubricant and glidant respectively. The prepared formulations were evaluated for pre-compression parameters like angle of repose, bulk density, tapped density, hausner’s index and carr’s index for granules while tablets were evaluated for various post-compression parameters like tablet thickness, hardness, weight variation, friability, content uniformity, disintegration time, and in-vitro drug release study. Pre-compression and post-compression evaluation showed that parameters evaluated were all found to be within the pharmacopoeial limits. Among all the formulations, L-3 and L-4 showed an optimum drug release of 94.16 % and 91.90 % over the period of 60 min respectively and thereby exhibited satisfactory drug release phenomenon for conventional oral tablets of Diclofenac sodium. 

Keywords: Diclofenac sodium, Lawsonia inermis, Mucilage, Binder, Conventional
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How to Cite
Joshi, Y., P. Bisht, A. Bhatt, D. Juyal, and S. Sade. “Utilization of Lawsonia Inermis Mucilage As a Novel Binder in Conventional Tablet Dosage Form”. Current Research in Pharmaceutical Sciences, Vol. 5, no. 1, Mar. 2015, pp. 17-23, http://crpsonline.com/index.php/crps/article/view/136.
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Research Articles