Synthesis and Biological Evaluation of Quinazolinone Fused Chalcone Derivatives as Anti-inflammatory Agents

  • Nancy Jain Computational and Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal (M.P.)
  • Nimisha Jain Computational and Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal (M.P.)
  • P K Singour Computational and Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Neelbud, Bhopal (M.P.)

Abstract

In the present study we have designed a new pharmacophore by pharmacophore hybridization approach of drug design. Quinazolinone nucleus has potent anti-inflammatory activities with nearly negligible ulcer index unlike other non steroidal anti-inflammatory drugs. Chalcone also have anti-inflammatory activity. Therefore, here we had tried to synthesize some of the novel quinazolinone fused chalcone derivatives and tested them for their anti-inflammatory activity. The structures of the compound have been confirmed by spectral analysis. Newly synthesized compounds were tested for anti-inflammatory activity using Rat hind paw method. Among the synthesized compounds 3-[1-(3, 4-dimethoxyphenyl)-3-(3-nitrophenyl) allylideneamino]-2-phenylquinazolin-4(3H)-one (4) were found to be most active.

Keywords: Quinazolinone, Schiff base, chalcone, anti-inflammatory activity.
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How to Cite
Jain, N., N. Jain, and P. K. Singour. “Synthesis and Biological Evaluation of Quinazolinone Fused Chalcone Derivatives As Anti-Inflammatory Agents”. Current Research in Pharmaceutical Sciences, Vol. 4, no. 1, Mar. 2014, pp. 15-20, http://crpsonline.com/index.php/crps/article/view/117.
Section
Research Articles