Anticonvulsant and CNS Depressant Activity of Methanolic Extracts of Whole Plant of Sida acuta and Sida rhombifolia in Mice

  • Veerendra Sharma Department of Pharmaceutical Sciences, LNAP,Gwalior
  • Pooja Sinoriya Department of Pharmaceutical Sciences, LNAP,Gwalior
  • S C Mehta G.R.Medical College, Gwalior, Madhya Pradesh

Abstract

To investigate the anticonvulsant and CNS depressant activity of methanolic extracts of whole plant of Sida acuta and Sida rhombifolia in mice. The methanolic extract of whole plant of Sida acuta (MESA) and Sida rhombifolia (MESR) (100, 200 and 400 mg/kg, p.o.) was studied for its anticonvulsant effect on maximal electroshock (MES) induced seizures and Pentylenetetrazole (PTZ) induced seizures and CNS depressant activity at the same dose level using traction test, rota rod and locomoter activity in mice. MESA and MESR at dose 100, 200 and 400 mg/kg significantly reduced the duration of the seizures as compared to control group. In CNS depressant activity and the mean time duration on rotating rod was significantly decreased (P<0.0001) and decline in motor co-ordination. 

Keywords: Sida acuta, Sida rhombifolia, MES, Pentylenetetrazole, CNS activity
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How to Cite
Sharma, V., P. Sinoriya, and S. C. Mehta. “Anticonvulsant and CNS Depressant Activity of Methanolic Extracts of Whole Plant of Sida Acuta and Sida Rhombifolia in Mice”. Current Research in Pharmaceutical Sciences, Vol. 3, no. 4, Dec. 2013, pp. 148-53, http://crpsonline.com/index.php/crps/article/view/113.
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Research Articles