Botanical Identity, Bioactive Principle, Antipyretic, Analgesic and Anti inflammatory Activities of Rungia repens (L) Nees

  • H K Sharma Department of Pharmacy, Karpagam University, Eachanari Post, Coimbatore-641 021, India.
  • V Alagarsamy Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy, Gr. Hyderabad -502 294, A.P. India.

Abstract

In this study we aimed to fix Rungia repens (L) Nees botanical identity, macroscopical, microscopical diagnostic characters and to isolate the bio-active principle responsible for biological actions shown by ethyl acetate and methanol extracts. Bioactive compounds were isolated by running column chromatography, characterized and percentage of activity of bioactive principle was calculated. Microscopical study reveals the characteristic nature of stomata, trichome, leaf mid rib and stem. The extracts were found to be non toxic upto the dose of 3000 mg/kg of Rungia repens ethyl acetate extract (RREAE) and methanolic extract (RRME) respectively. RREAE and RRME produced a significant and dose dependent inhibition of analgesic, anti inflammatory and antipyretic activity. Bioactive principle isolated was a flavonoid luteolin shows maximum activity equal to that of standard drug. We believe that the antipyretic, analgesic, and anti-inflammatory activity of the RREAE and RRME were due to its bioactive principle flavonoid luteolin present in the extract. 

Keywords: Rungia repens, quantitative microscopy, anti pyretic, analgesic, anti inflammatory and luteoline
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How to Cite
Sharma, H. K., and V. Alagarsamy. “Botanical Identity, Bioactive Principle, Antipyretic, Analgesic and Anti Inflammatory Activities of Rungia Repens (L) Nees”. Current Research in Pharmaceutical Sciences, Vol. 3, no. 4, Dec. 2013, pp. 122-31, http://crpsonline.com/index.php/crps/article/view/109.
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Research Articles