Current Research in Pharmaceutical Sciences 2016; 06 (02): 50-54
ISSN: 2250-2688

Research Paper

Formulation and Evaluation of Fast Dissolving Tablet of Glimepiride

Bhawna Mishra, Rizwana Khan, Manish Rajoriya and Anil Kharia

ABSTRACT

Glimepiride is a first third generation sulphonyl urea agent for the treatment type II diabetes mellitus. The main objective of present work was to formulate and evaluate fast dissolving tablet of glimepiride by using different concentration of super disintegrating agents. Glimepiride is given once daily in doses from 1-8 mg. The fast dissolving tablets of glimepiride was prepared from F1- F4 by direct compression method.The drug and excipients were evaluated for angle of repose, bulk density, tapped density, Carr’s index and hausner’s ratio for the determination of flow property of powder. The formulated tablets were evaluated for thickness, hardness, friability, wetting time, water absorption and dispersion time. The obtained results were clearly indicating that the formulated tablets results are within the range and when compared with all formulations, F4 was the best formulation among the four formulations.

Keywords: Glimepiride, Fast Dissolving Tablet, Direct Compression Method and super disintegrating agents

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